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Mechanism of action of penicillin: triggering of the pneumococcal autolytic enzyme by inhibitors of cell wall synthesis

Proceedings of the National Academy of Sciences of the United States of America

Oct 1, 1975

Alexander Tomasz, S Waks

PMID: 674

Abstract

During penicillin treatment of an autolysin defective mutant pneumococcus we have observed three novel phenomena: (i) Growth of the mutant cultures is inhibited by the same concentrations of penicillin that induce lysis in the wild type. (ii) Mutant bacteria treated with the minimum gro...read more

Mentioned in this Paper

Penicillin
Streptococcus pneumoniae
Autolysis
Teichoic Acids
Cell Wall
Syntomycin
Lysosomal Storage Diseases
Deoxycholic Acid, Sodium Salt, 12beta-Isomer
Enzyme Activation
67
Paper Details
References
  • References8
  • Citations94
12345...

Mechanism of action of penicillin: triggering of the pneumococcal autolytic enzyme by inhibitors of cell wall synthesis

Proceedings of the National Academy of Sciences of the United States of America

Oct 1, 1975

Alexander Tomasz, S Waks

PMID: 674

DOI:

Abstract

During penicillin treatment of an autolysin defective mutant pneumococcus we have observed three novel phenomena: (i) Growth of the mutant cultures is inhibited by the same concentrations of penicillin that induce lysis in the wild type. (ii) Mutant bacteria treated with the minimum gro...read more

Mentioned in this Paper

Penicillin
Streptococcus pneumoniae
Autolysis
Teichoic Acids
Cell Wall
Syntomycin
Lysosomal Storage Diseases
Deoxycholic Acid, Sodium Salt, 12beta-Isomer
Enzyme Activation
67

Related Papers

Paper Details
References
  • References8
  • Citations94
12345...
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