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Mechanism of action of penicillin: triggering of the pneumococcal autolytic enzyme by inhibitors of cell wall synthesis

Proceedings of the National Academy of Sciences of the United States of America

Oct 1, 1975

Alexander Tomasz, S B Waks

PMID: 674

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Abstract

During penicillin treatment of an autolysin defective mutant pneumococcus we have observed three novel phenomena: (i) Growth of the mutant cultures is inhibited by the same concentrations of penicillin that induce lysis in the wild type. (ii) Mutant bacteria treated with the minimum gro...read more

Mentioned in this Paper

Teichoic Acids
Lysosomal Storage Diseases
Enzyme Activation
Cell Wall
Streptococcus pneumoniae
Deoxycholic Acid, Sodium Salt, 12beta-Isomer
Syntomycin
Penicillin
Autolysis
64
Paper Details
References
    • References8
    • Citations89
    • References8
    • Citations89
  • Mechanism of action of penicillin: triggering of the pneumococcal autolytic enzyme by inhibitors of cell wall synthesis

    Proceedings of the National Academy of Sciences of the United States of America

    Oct 1, 1975

    Alexander Tomasz, S B Waks

    PMID: 674

    DOI:

    Abstract

    During penicillin treatment of an autolysin defective mutant pneumococcus we have observed three novel phenomena: (i) Growth of the mutant cultures is inhibited by the same concentrations of penicillin that induce lysis in the wild type. (ii) Mutant bacteria treated with the minimum gro...read more

    Mentioned in this Paper

    Teichoic Acids
    Lysosomal Storage Diseases
    Enzyme Activation
    Cell Wall
    Streptococcus pneumoniae
    64

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    Paper Details
    References
    • References8
    • Citations89
    • References8
    • Citations89
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