PMID: 1520Nov 1, 1975

Mechanism of action of pentagastrin and acetylcholine on the longitudinal muscle of the canine antrum

The Journal of Physiology
J H Szurszewski


1. Electrical and mechanical activities of the longtitudinal muscle of the dog antrum were recorded with the double sucrose-gap technique. 2. The muscle exhibited spontaneous action potentials which consisted of a spike-like potential which, after a brief and partial repolarization, was followed by a negative-going, plateau-type potential. In 97% of the preparations, no tension changes were produced by spontaneous action potentials. 3. Tetrodotoxin, atropine, alpha- and beta-adrenoceptor antagonists, and H1 and H2 receptor blocking agents had no effect on the action potential. It was concluded that the action potential was myogenic in origin. 4. The mean frequency of the action potential at 37+/- 0.5 degrees C was 1.0/min+/-0.06 (s.e. of mean, n=92) and the mean duration 7.1+/-0.2 sec (s.e. of mean, n=11). 5. Steady depolarizing current increased whereas hyperpolarizing current decreased the frequency of the action potential. 6. Length-tension relations were studied. In twelve strips, the average resting, passive, tension at LO was 570 mg. The active force of isometric contraction produced by acetylcholine increased with strip length up to a maximum, then decreased wtih further increased in length. There were no mechanical resp...Continue Reading


Mar 1, 1980·Digestive Diseases and Sciences·A J SmoutJ L Grashuis
Jan 1, 1988·Baillière's Clinical Gastroenterology·V StanghelliniL Barbara
Sep 20, 1979·World Journal of Surgery·P A ThomasK A Kelly
Feb 1, 1988·Digestive Diseases and Sciences·C H KimJ R Malagelada
Nov 20, 1992·Regulatory Peptides·A W Mangel, I L Taylor
Jan 1, 1985·General Pharmacology·K FujiiT Yoshitomi
Oct 1, 1989·Scandinavian Journal of Gastroenterology·S S SimM S Kim
Jan 16, 2003·The Journal of Physiology·Tae Wan KimK M Sanders
Nov 17, 2001·The Journal of Physiology·K HoriguchiSean M Ward
Mar 1, 1986·Mayo Clinic Proceedings·C H Kim, J R Malagelada
Apr 7, 2015·Journal of Neurogastroenterology and Motility·Amy A WorthK M Sanders
Apr 1, 1999·Annual Review of Physiology·B HorowitzK M Sanders
Jul 4, 2017·Experimental Physiology·Sean P Parsons, Jan D Huizinga
Jul 1, 1980·Pflügers Archiv : European journal of physiology·Y Hara
Sep 30, 2017·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·G L HeyerM J Cismowski
Jan 9, 2008·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·R AvivE E Soffer
Jan 19, 2005·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Kenro ImaedaMakoto Itoh
Nov 4, 2016·Nature Reviews. Gastroenterology & Hepatology·K M SandersGrant W Hennig
May 1, 1983·The American Journal of Physiology·K M Sanders
May 1, 1991·The American Journal of Physiology·H OzakiK M Sanders
Sep 1, 1978·The American Journal of Physiology·K G MorganJ H Szurszewski

Related Concepts

Acetylcholine Sulfate (1: 1)
Nerve Impulses
Adrenergic alpha-Agonists
Adrenergic beta-Agonists
Canis familiaris
Smooth Muscle

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.