PMID: 1520Nov 1, 1975

Mechanism of action of pentagastrin and acetylcholine on the longitudinal muscle of the canine antrum

The Journal of Physiology
J H Szurszewski

Abstract

1. Electrical and mechanical activities of the longtitudinal muscle of the dog antrum were recorded with the double sucrose-gap technique. 2. The muscle exhibited spontaneous action potentials which consisted of a spike-like potential which, after a brief and partial repolarization, was followed by a negative-going, plateau-type potential. In 97% of the preparations, no tension changes were produced by spontaneous action potentials. 3. Tetrodotoxin, atropine, alpha- and beta-adrenoceptor antagonists, and H1 and H2 receptor blocking agents had no effect on the action potential. It was concluded that the action potential was myogenic in origin. 4. The mean frequency of the action potential at 37+/- 0.5 degrees C was 1.0/min+/-0.06 (s.e. of mean, n=92) and the mean duration 7.1+/-0.2 sec (s.e. of mean, n=11). 5. Steady depolarizing current increased whereas hyperpolarizing current decreased the frequency of the action potential. 6. Length-tension relations were studied. In twelve strips, the average resting, passive, tension at LO was 570 mg. The active force of isometric contraction produced by acetylcholine increased with strip length up to a maximum, then decreased wtih further increased in length. There were no mechanical resp...Continue Reading

Citations

Mar 1, 1980·Digestive Diseases and Sciences·A J SmoutJ L Grashuis
Jan 1, 1988·Baillière's Clinical Gastroenterology·V StanghelliniL Barbara
Sep 20, 1979·World Journal of Surgery·P A ThomasK A Kelly
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Oct 1, 1989·Scandinavian Journal of Gastroenterology·S S SimM S Kim
Jan 16, 2003·The Journal of Physiology·Tae Wan KimK M Sanders
Nov 17, 2001·The Journal of Physiology·K HoriguchiSean M Ward
Mar 1, 1986·Mayo Clinic Proceedings·C H Kim, J R Malagelada
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Jul 4, 2017·Experimental Physiology·Sean P Parsons, Jan D Huizinga
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May 1, 1983·The American Journal of Physiology·K M Sanders
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Related Concepts

Acetylcholine Sulfate (1: 1)
Nerve Impulses
Adrenergic alpha-Agonists
Adrenergic beta-Agonists
Atropen
Calcium
Canis familiaris
Inotropism
Smooth Muscle
Peptavlon

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