Mechanism of action of pyrogen

The Journal of Physiology
W Feldberg, P N Saxena


1. In unanaesthetized rabbits the cerebral ventricles were perfused for 30-75 min from left lateral ventricle to cisterna magna with solutions of different composition, whilst rectal temperature was continuously recorded.2. Temperature did not rise during the perfusion when the perfusing fluid consisted of artificial c.s.f.; it did rise, however, when the perfusing fluid consisted merely of a 0.9% sodium chloride solution.3. Temperature fell, though not in all rabbits, during the perfusion when the calcium in the perfusing fluid was increased from 1.25 mM, the concentration in c.s.f. to 5 mM.4. Magnesium chloride had only a weak action, in comparison to calcium, in preventing the rise produced during perfusion with 0.9% sodium chloride solution. In a concentration of 1.25 mM it had no effect, but in a concentration of 5 mM it delayed and greatly reduced the rise.5. Temperature did not rise during perfusion with an isotonic sucrose solution.6. The rise in temperature produced by an intravenous injection of leucocyte pyrogen was not prevented when the injection was made during a perfusion with artificial c.s.f., but it was prevented when the calcium concentration in the perfusing fluid was raised to 5 mM or when the perfusing flu...Continue Reading


Jan 1, 1976·Experientia·G A Balint
Jan 1, 1977·Brain Research Bulletin·W L VealeT Malkinson
Feb 1, 1976·British Journal of Pharmacology·P N Saxena

Related Concepts

Calcium [EPC]
Magnesium Measurement
Structure of Cisterna Magna
Intravenous Injections
Calcium ion
Hypothalamus, Anterior
Injection Procedure

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