PMID: 9552353Jan 1, 1995Paper

Mechanism of action of rapamycin: new insights into the regulation of G1-phase progression in eukaryotic cells

Progress in Cell Cycle Research
G J WiederrechtR T Abraham

Abstract

The immunosuppressant drug, rapamycin (RAP), is a potent inhibitor of IL-2-dependent T-cell proliferation. The antiproliferative effect of RAP is mediated through the formation of an active complex with its cytosolic receptor protein, FKBP12. The molecular target of the FKBP12.RAP complex is a putative lipid kinase termed the mammalian Target Of Rapamycin (mTOR). This review will discuss recent findings suggesting that mTOR is a novel regulator of G1- to S-phase progression in eukaryotic cells.

Citations

Jul 14, 2000·Journal of Hematotherapy & Stem Cell Research·D Simpson
Jun 5, 2002·Plastic and Reconstructive Surgery·Terence M MyckatynSusan E Mackinnon
Sep 2, 2003·Molecular Carcinogenesis·Masaaki NomuraZigang Dong
Apr 9, 2004·Blood·Thomas StrömbergHelena Jernberg-Wiklund
Dec 23, 2004·Transplant International : Official Journal of the European Society for Organ Transplantation·Markus GubaEdward K Geissler
Apr 1, 2005·The New England Journal of Medicine·Giovanni StalloneGiuseppe Grandaliano
Jun 26, 2007·Current Oncology Reports·Monica M Mita, Anthony W Tolcher
May 6, 2008·British Journal of Pharmacology·J H HolsteinM D Menger
Nov 18, 2008·Expert Opinion on Investigational Drugs·Monica MitaFrancis Giles
Dec 9, 2008·Current Opinion in Organ Transplantation·Eugenia Raichlin, Sudhir S Kushwaha
Mar 11, 2011·Cell Cycle·Philip A GruppusoJennifer A Sanders
Oct 7, 2014·PloS One·Arvind K SinglaJaved N Agrewala
May 16, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Luokun XieKunlin Jin
Mar 17, 2017·Journal of Ophthalmic & Vision Research·Tulio B AbudReza Dana
May 7, 2020·Frontiers in Chemistry·Nihay Laham-KaramPiia Kokkonen
Jan 31, 2004·Current Oncology Reports·Janice P Dutcher
Mar 17, 2004·Transplantation·Josep M CampistolJ Vicente Torregrosa
Oct 8, 2005·Transplantation·Barry D KahanCharles T Van Buren
Jun 24, 2008·BMC Cancer·Elena V SvirshchevskayaLyuba Varticovski
Aug 7, 2012·Journal of Mammary Gland Biology and Neoplasia·Justin Cidado, Ben Ho Park
Apr 5, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·P G StockUNKNOWN for Solid Organ Transplantation in HIV Study Investigators
Oct 26, 2016·Transplantation·Jeffrey Steven Zaltzman
Jan 1, 2014·3 Biotech·Subhasish DuttaApurba Dey
Oct 27, 2017·European Respiratory Review : an Official Journal of the European Respiratory Society·Rana Kanaan, Charlie Strange
Aug 14, 2019·Clinical and Experimental Immunology·C LiuZ Dai
Mar 5, 2005·Blood·Manuela BattagliaMaria-Grazia Roncarolo
May 24, 2008·Transplant International : Official Journal of the European Society for Organ Transplantation·Giovanni StalloneLoreto Gesualdo
May 15, 2010·Expert Opinion on Emerging Drugs·Bruno VincenziGiuseppe Tonini
Aug 12, 2010·Cellular Reprogramming·Charles A EasleyGerald P Schatten
Jun 9, 2007·Expert Review of Anticancer Therapy·Jin-Young ParkRobert H Weiss
Jul 24, 2010·Molecular Human Reproduction·Travis C ThomsonJoshua Johnson
Jul 20, 2010·Immunotherapy·Jorieke H PetersIrma Joosten
Nov 17, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mario GalganiGiuseppe Matarese
Dec 20, 2011·Endocrine-related Cancer·David A PotterMariangellys Rodriguez

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