PMID: 39894Aug 1, 1979

Mechanism of action of Yersinia enterocolitica enterotoxin

Infection and Immunity
R M Robins-BrowneH J Koornhof


Enterotoxin derived from three clinical isolates of Yersinia enterocolitica was compared with the heat-stable enterotoxin of Escherichia coli. Both toxins were biologically active in infant mice examined at 2 h and in ligated rabbit ileal loops at 6 h. Neither substance, however, produced changes in ligated ileal loops at 18 h or in Chinese hamster ovary or Y1 adrenal tissue cultures. In addition, both Y. enterocolitica enterotoxin concentrated approximately 20 times by ammonium sulfate precipitation and ultrafiltration and a similarly prepared sample of E. coli heat-stable enterotoxin stimulated the activity of guanylate cyclase but not that of adenylate cyclase in infant mouse intestine. These findings suggest that the role of enterotoxin in the pathogenesis of intestinal Y.enterocolitica infection may be similar to that of heat-stable enterotoxin in E. coli diarrhea.


Jan 1, 1994·Critical Reviews in Microbiology·Y u PolotskyT h Khavkin
Jan 1, 1983·Transactions of the Royal Society of Tropical Medicine and Hygiene·M Lopez-Brea, M L Jimenez
Jan 1, 1980·Microbiology and Immunology·K OkamotoS Yoshii
Sep 1, 1994·Scandinavian Journal of Gastroenterology·W GogartenJ D Schulzke
Aug 26, 2006·Journal of Veterinary Medicine. B, Infectious Diseases and Veterinary Public Health·A Platt-SamorajZ Procajło
Jul 6, 1989·The New England Journal of Medicine·T L Cover, R C Aber

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