Mechanism of adenovirus neutralization by Human alpha-defensins

Cell Host & Microbe
Jason G Smith, Glen R Nemerow

Abstract

Defensins are naturally occurring antimicrobial peptides that disrupt bacterial membranes and prevent bacterial invasion of the host. Emerging studies indicate that certain defensins also block virus infection; however, the mechanism(s) involved are poorly understood. We demonstrate that human alpha-defensins inhibit adenovirus infection at low micromolar concentrations, and this requires direct association of the defensin with the virus. Moreover, defensins inhibit virus disassembly at the vertex region, thereby restricting the release of an internal capsid protein, pVI, which is required for endosomal membrane penetration during cell entry. As a consequence, defensins hamper the release of adenovirus particles from endocytic vesicles, resulting in virion accumulation in early endosomes and lysosomes. Thus, defensins possess remarkably distinct modes of activity against bacteria and viruses, and their function may provide insights for the development of new antiviral strategies.

References

Oct 1, 1985·The Journal of Clinical Investigation·T GanzR I Lehrer
May 26, 1999·The British Journal of Ophthalmology·R J HaynesH S Dua
Aug 10, 2001·Regulatory Peptides·A Bastian, H Schäfer
May 13, 2003·Reviews in Medical Virology·Tsoline KojaoghlanianMarshall S Horwitz
Sep 2, 2003·Nature Reviews. Immunology·Tomas Ganz
Feb 26, 2004·The European Respiratory Journal·R Bals, P S Hiemstra
Jul 28, 2004·The American Journal of Pathology·Cristiano RumioAndrea Balsari
Oct 28, 2004·Journal of Virology·Robin VargheseRobert Ralston
Feb 1, 2005·Journal of Virology·Christopher M WiethoffGlen R Nemerow
Feb 11, 2005·Nature Reviews. Microbiology·Kim A Brogden
Feb 19, 2005·The Journal of Clinical Investigation·Theresa L ChangMary E Klotman
May 24, 2005·Nature Immunology·Michael E Selsted, Andre J Ouellette
Jul 5, 2005·Bioorganic & Medicinal Chemistry·W Seth HorneGlen R Nemerow
Sep 13, 2005·Nature Immunology·Eugenia LeikinaLeonid V Chernomordik
Jan 25, 2006·Proceedings of the National Academy of Sciences of the United States of America·Christopher B BuckJohn T Schiller
May 2, 2006·The Journal of Biological Chemistry·Stephen A GalloRobert Blumenthal
Nov 17, 2006·Journal of Virology·Milena Iacobelli-Martinez, Glen R Nemerow
Nov 30, 2006·Current Opinion in Hematology·Robert I Lehrer
Dec 21, 2006·Molecular Therapy : the Journal of the American Society of Gene Therapy·Ronald R NepomucenoGlen R Nemerow
Mar 14, 2007·The Journal of Allergy and Clinical Immunology·Michael D HowellDonald Y M Leung

❮ Previous
Next ❯

Citations

May 8, 2013·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Emily Gwyer FindlayDonald J Davidson
Mar 12, 2010·The Journal of Biological Chemistry·Gang WeiWuyuan Lu
May 29, 2012·The Journal of Biological Chemistry·Anshu P GounderJason G Smith
Jun 27, 2012·The Journal of Biological Chemistry·Lusine H DemirkhanyanGregory B Melikyan
Sep 11, 2008·The Journal of Biological Chemistry·Aisling S DuganWalter J Atwood
Jun 1, 2012·Journal of Virology·W A McEwanL C James
Jun 6, 2008·Journal of Virology·Lars PacheGlen R Nemerow
Aug 3, 2012·Journal of Virology·Oana MaierChristopher M Wiethoff
Jan 7, 2011·Journal of Virology·Crystal L MoyerGlen R Nemerow
Dec 28, 2012·Journal of Virology·Joost SnijderGijs J L Wuite
Sep 24, 2008·Journal of Dental Research·G DiamondL K Ryan
Feb 24, 2012·PloS One·John David SpencerAndrew L Schwaderer
May 14, 2014·PloS One·Dong-Qiang ChengJing-Fei Huang
Jul 18, 2014·PLoS Pathogens·Mayim E WiensJason G Smith
Mar 4, 2011·Future Microbiology·Daniel HenaffEric J Kremer
Jul 9, 2011·Future Virology·Seth M GregoryJordan P Metcalf
Jun 5, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·John David SpencerDavid S Hains
Feb 12, 2014·Human Gene Therapy·Rodinde HendrickxUrs F Greber
Jan 1, 2014·Annual Review of Virology·Christopher M Robinson, Julie K Pfeiffer
Jun 3, 2009·Expert Review of Vaccines·Erin E ThackerQiana L Matthews
Mar 13, 2014·Journal of Molecular Biology·Joost SnijderAlbert J R Heck
Oct 8, 2013·Journal of Molecular Biology·Sarah S WilsonJason G Smith
Nov 8, 2011·Infectious Disease Clinics of North America·K Noel Masihi, Hubert Schäfer
Oct 23, 2008·Traffic·Agnieszka A BrzezinskaSergio D Catz
Jul 27, 2015·Drug Discovery Today·Pablo Martínez-AguadoJavier Sánchez-Céspedes
Dec 18, 2008·The Journal of General Virology·W C Russell
Jun 8, 2014·Antiviral Research·Javier Sanchez-CespedesGlen R Nemerow
Jan 15, 2008·Cell Host & Microbe·Christopher B Buck
Dec 22, 2009·Blood·Mark K LaffertyAlfredo Garzino-Demo
Feb 16, 2016·Traffic·Yohei Yamauchi, Urs F Greber

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.