Mechanism of age-associated up-regulation in macrophage PGE2 synthesis

Brain, Behavior, and Immunity
Dayong Wu, S N Meydani

Abstract

Many physiological functions of the body change during the aging process. Dysregulated immune and inflammatory responses have been well documented in both humans and animals. The investigation into the cellular and molecular mechanism underlying these disorders has provided compelling evidence that up-regulated cyclooxygenase (COX)-2 and its product, particularly prostaglandin (PG)E2, play a critical role in the age-associated dysregulation of the immune and inflammatory responses. In particular, several studies have shown that increased PGE2 production in old macrophages (Mphi) contributes to the suppression of T cell function with aging. Furthermore, interventions targeted at decreasing PGE2 production have been shown to enhance T cell-mediated function. COX-2 and its catalytic products are also suggested to play a key role in age-related neurodegenerative diseases such as Alzheimer's and Parkinson's disease. Administration of anti-inflammatory drugs which inhibit COX activity has been shown, by some investigators, to be beneficial in preventing and treating these diseases. It is, thus, important to understand the underlying mechanisms of age-related COX-2 up-regulation and to delineate the factors, which contribute to this a...Continue Reading

References

Dec 1, 1989·Prostaglandins·T W WilsonT A Waslen
Feb 1, 1993·Mechanisms of Ageing and Development·R A FranklinK W Kelley
Dec 22, 1995·The Journal of Biological Chemistry·M E VenableL M Obeid
Feb 26, 2000·Vaccine·R A Miller
Feb 28, 2002·Trends in Immunology·Sarah G HarrisRichard P Phipps
May 7, 2002·Journal of Pain and Symptom Management·Paul S Aisen
May 16, 2002·International Immunopharmacology·Bianca Rocca, Garret A FitzGerald
Jun 20, 2002·The Journal of Biological Chemistry·Kate J ClaycombeSimin Nikbin Meydani
Sep 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·N V ChandrasekharanDaniel L Simmons
Nov 16, 2002·Prostaglandins & Other Lipid Mediators·Nicolas G BazanWalter J Lukiw
Apr 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Peter TeismannSerge Przedborski
Jan 6, 2004·Proceedings of the National Academy of Sciences of the United States of America·Stéphane HunotRichard A Flavell
Jan 30, 2004·Nature Immunology·Phyllis Jean Linton, Kenneth Dorshkind

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Citations

Jun 9, 2005·The Journal of Allergy and Clinical Immunology·Susanna Cunningham-RundlesAeri Moon
May 9, 2006·Antioxidants & Redox Signaling·Hae Young ChungByung Pal Yu
Nov 23, 2011·The Journal of Clinical Investigation·Thomas J Braciale, Taeg S Kim
Nov 21, 2015·Organogenesis·Elizabeth C Stahl, Bryan N Brown
Mar 31, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Huxing CuiAkitoyo Hishimoto
Jan 24, 2009·Behavioural Brain Research·Cristina B GuzmánAmy H Moore
Dec 13, 2006·Translational Research : the Journal of Laboratory and Clinical Medicine·Khong Bee KangHenryk Majewski
Feb 13, 2009·Hemodialysis International·Natalia C V MeloHugo Abensur
Aug 19, 2007·Experimental Dermatology·Laurent ColombeBruno Alain Bernard
Jan 8, 2014·Photodermatology, Photoimmunology & Photomedicine·Mohammed Ahmad HabibYahia Ahmad Mostafa Shalan
Jun 25, 2005·Experimental Gerontology·Elizabeth J Kovacs
Sep 21, 2013·Biochemical and Biophysical Research Communications·Huimin ChenXiaochun Teng
Sep 21, 2013·Biochimica Et Biophysica Acta·Sébastien MartienCorinne Abbadie
Apr 20, 2016·Progress in Neurobiology·Neha Vartak-SharmaAnuja Ghorpade
Dec 4, 2008·Plastic and Reconstructive Surgery·Siamak Agha-Mohammadi, Dennis J Hurwitz
Oct 12, 2018·Current Medicinal Chemistry·Kustrimovic NatasaMarco Cosentino
May 31, 2019·Endocrine, Metabolic & Immune Disorders Drug Targets·Ibrahim Elmadfa, Alexa L Meyer
Feb 5, 2008·Nutrition Reviews·Simin Nikbin Meydani, Dayong Wu
Jan 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Konstantin V SalojinTamas Oravecz
Jan 22, 2021·Nature·Paras S MinhasKatrin I Andreasson
Aug 22, 2021·Antioxidants & Redox Signaling·Mihály BaloghAndrew John Shepherd
Sep 14, 2021·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Constanze A JakwerthUlrich M Zissler

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