PMID: 1198067Nov 1, 1975Paper

Mechanism of anaemia in experimental bacterial endocarditis

Scandinavian Journal of Haematology
R A Joyce, M A Sande

Abstract

Rabits with Streptococcus viridans aortic valve endocarditis develop anaemia and reticulocytosis which increase with the duration of infection. Mean red cell counts decreased from 6.05 +/- 0.29 X 10(6) per mul before infection to 4.10 +/- 0.18 X 10(6) per mul after 11 to 20 days of endocarditis and reticulocytes increased from 1.16 +/- 0.14 X 10(5) per mul to 4.91 +/- 0.83 X 10(5) per mul after more than 20 days of endocarditis. The anaemia could not be explained by intravascular haemolysis. Anti-erythrocyte antibodies were not detected. Splenomegaly was a consistent finding and also increased with the duration of infection. Red cell half life (T1/2) was shortened to 4.7 +/- 0.3 days in rabbits with endocarditis compared with normal T1/2 of 11.1 +/- 0.5 days. The T1/2 of red cells from infected animals was prolonged when measured in noninfected rabbits and splenectomized animals had a mean red cell T1/2 of 9.25 days after three weeks of infection. These studies suggest that splenic enlargement associated with infection results in red cell sequestration, a mechanism not well recognized as contributing to the anaemia of endocarditis.

References

Apr 1, 1974·The Journal of Clinical Investigation·S ZuckerR M Lysik
May 1, 1974·The Journal of Infectious Diseases·M A Sande, R G Irvin
Jan 1, 1956·The Journal of Clinical Investigation·J A BUSHM M WINTROBE
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Dec 1, 1950·The Journal of Clinical Investigation·K STERLING, S J GRAY

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