Mechanism of Anti-α-Synuclein Immunotherapy

Journal of Movement Disorders
Jun Sung Lee, Seung-Jae Lee

Abstract

Immunization therapy targeting α-synuclein has emerged as a promising approach for Parkinson's disease and perhaps for other synucleinopathies. Several antibodies have shown therapeutic effects in mouse models of synucleinopathies and have alleviated the pathological and behavioral phenotypes of these mice. The mechanisms through which the immunization therapy works were initially puzzling, especially given that α-synuclein is a typical cytosolic protein. Recent studies, however, suggested that extracellular α-synuclein is an important pathogenic entity, and hence, a target for immunotherapy. Here, we review the literature describing immunization therapy for synucleinopathies in mouse models and provide current thoughts on the potential mechanisms underlying the therapeutic effects of α-synuclein immunotherapy.

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Citations

Feb 2, 2016·Journal of Movement Disorders·Yun Joong Kim
May 26, 2017·The Tohoku Journal of Experimental Medicine·Takafumi HasegawaMasashi Aoki
Feb 8, 2018·Journal of Medicinal Food·Un Ju Jung, Sang Ryong Kim
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May 28, 2021·CNS & Neurological Disorders Drug Targets·Jet Shee TengRhun Yian Koh

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Methods Mentioned

BETA
transgenic

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