Mechanism of antidiabetic and synergistic effects of ginseng polysaccharide and ginsenoside Rb1 on diabetic rat model

Journal of Pharmaceutical and Biomedical Analysis
Jing LiShanshan Yu

Abstract

Ginseng polysaccharides (GP) have been reported to modulate gut microbiota, and ginsenoside Rb1 is known to display significant hypoglycemic activity. However, the synergistic effect of Rb1 and GP when applied to diabetic treatment remains largely unknown. Male rats were divided into ten groups: blank group (B-Group), model group (D-Group), Rb1 group (Rb1-Group), CK group (CK-Group), GP groups and GP + Rb1 groups in dosage of high, middle and low (H-Group, M-Group, L-Group, H-Rb1-Group, M-Rb1-Group, and L-Rb1-Group). CK-Group, GP groups and Rb1 group were fed CK, GP and Rb1 for 30 days, respectively. GP + Rb1 groups were fed GP on the initial 15 days and GP and Rb1 on the final 15 days. The fasting glucose of all groups was measured every five days. The transformation of Rb1 in vitro by rat intestinal microflora, which was collected from the B-Group, D-Group and GP groups on the 15th day, was investigated using HPLC and RRLC-Q-TOF/MS. Analyses the of 16S rRNA gene of the fecal bacterial population and fecal β-glucosidase activity were conducted among the B-Group, D-Group and H-Group. Compared with those of rats in the D-Group, the fasting glucose levels of rats in the CK-Group and H-Rb1-Group decreased highest. During transform...Continue Reading

Citations

Nov 6, 2018·Canadian Journal of Physiology and Pharmacology·Morris Karmazyn, Xiaohong Tracey Gan
Aug 21, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Si-Wen ZhengYing-Ping Wang
Aug 11, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Huai-You WangKarl W K Tsim
Jul 27, 2021·World Journal of Clinical Cases·Xuan-Yin ZhaoXiao-Ya Jiang
Aug 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hongyu QiXiangyan Li

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