PMID: 9524925Apr 3, 1998Paper

Mechanism of arachidonic acid-induced Ca2+ mobilization in liver nuclei

Journal of Lipid Mediators and Cell Signalling
R E CatalánA M Martínez

Abstract

Arachidonic acid treatment in isolated liver nuclei resulted in a rapid and transient increase of Ca2+ concentration in the nucleoplasm which was monitored with the Ca(2+)-sensitive dye fura-2 dextran. This effect was associated with a decrease of Ca2+ concentration in the nuclear envelope as measured with fura-2 AM. Our results indicate that arachidonic acid causes a Ca2+ release from the nuclear envelope to the nucleoplasm similar to that evoked by inositol trisphosphate (IP3). The arachidonic acid-induced Ca2+ mobilization in the nucleus was not due to the metabolites of arachidonic acid. Experiments performed in the presence of ATP and Ca2+ indicate that arachidonic acid-induced Ca2+ mobilization in the nucleus takes place in a non ATP-dependent way. Taken together, these results suggest that arachidonic acid may contribute to the regulation of nuclear Ca2+ mobilization.

References

Aug 14, 1992·Biochimica Et Biophysica Acta·O BachsE Carafoli
Jan 1, 1991·Annals of the New York Academy of Sciences·B SamuelssonA Wetterholm
Mar 15, 1988·European Journal of Biochemistry·R E CatalánF Hernandez
Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·P NicoteraS Orrenius
Oct 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·M VolpiR I Sha'afi
Mar 1, 1995·Cellular Signalling·R E CatalánF Hernández
Dec 20, 1994·Proceedings of the National Academy of Sciences of the United States of America·N L AllbrittonT Meyer
Jun 15, 1994·Molecular and Cellular Biochemistry·J S GilchristG N Pierce
Feb 24, 1994·Nature·F A al-MohannaS R Bolsover
Aug 13, 1993·Cell·N DivechaR F Irvine
Feb 1, 1993·Circulation Research·D S Damron, M Bond

❮ Previous
Next ❯

Related Concepts

Related Feeds

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.