Mechanism of benefit of negative inotropes in obstructive hypertrophic cardiomyopathy

Circulation
M V SherridD Z Gunsburg

Abstract

Drugs with negative inotropic effect are widely used to decrease obstruction in hypertrophic cardiomyopathy (HCM). However, the mechanism of therapeutic benefit has not been studied. We used M-mode, two-dimensional, and pulsed Doppler echocardiography to study 11 patients with obstructive HCM before and after medical elimination of left ventricular outflow tract obstruction. We measured 148 digitized pulsed Doppler tracings recorded in the left ventricular cavity 2.5 cm apical of the mitral valve. Successful treatment slowed average acceleration of left ventricular ejection by 34% (P=.001). Mean time to peak velocity in the left ventricle was prolonged 31% (P=.001). Mean time to an ejection velocity of 60 cm/s was prolonged 91% (P=.001). Before treatment, left ventricular ejection velocity peaked in the first half of systole; after successful treatment, it peaked in the second half (P=.001). In contrast, after treatment, we found no change in peak left ventricular ejection velocity. We also found no change in the distance between the mitral coaptation point and the septum, as measured in two planes, indicating no treatment-induced alteration of this anatomic relationship. Medical treatment eliminates mitral-septal contact and o...Continue Reading

References

Jun 1, 1979·The American Journal of Cardiology·B J Maron, S E Epstein
Mar 15, 1990·Journal of the American College of Cardiology·A Pasipoularides
May 1, 1989·Journal of the American College of Cardiology·Z SassonE D Wigle
May 1, 1989·Journal of the American College of Cardiology·E G CapeR A Levine
Nov 1, 1986·Journal of the American College of Cardiology·P G YockR L Popp
Nov 15, 1988·The American Journal of Cardiology·M SherridE Dwyer
Apr 1, 1988·Journal of the American College of Cardiology·Z SassonR L Popp
Jun 1, 1973·The American Journal of Cardiology·R E StensonE W Hancock
Dec 1, 1980·The Journal of Clinical Investigation·J P MurgoG M McGranahan
Nov 1, 1983·American Heart Journal·J M GardinW L Henry
Oct 14, 1982·The New England Journal of Medicine·C Pollick
Nov 15, 1993·The American Journal of Cardiology·M Kupari, P Koskinen
Sep 1, 1993·Journal of the American College of Cardiology·M V SherridE M Dwyer
Oct 27, 1997·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·M V SherridG Pearle
Aug 1, 1963·The American Journal of Physiology·P F SALISBURYP A RIEBEN
Mar 1, 1964·The Journal of Clinical Investigation·R R HERNANDEZB W MCCALL

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Citations

Nov 26, 2008·Current Treatment Options in Cardiovascular Medicine·Caroline J Coats, Perry M Elliott
Dec 4, 2003·Heart & Lung : the Journal of Critical Care·Lynn M Charls
Nov 7, 2002·International Journal of Cardiology·Faisal Al-NasserMichael Y Henein
Feb 1, 2003·International Journal of Cardiology·Giuseppe Barletta
Aug 24, 1999·International Journal of Cardiology·G BarlettaF Fantini
Jan 24, 2003·The New England Journal of Medicine·Martin S MaronBarry J Maron
Jun 22, 2012·European Heart Journal·Roberto SpoladoreIacopo Olivotto
Jan 5, 2001·The Journal of Cardiovascular Nursing·L S Evangelista, J Chen
Sep 19, 2009·Journal of Cardiothoracic Surgery·Aron F PopovFriedrich A Schoendube
Nov 7, 2002·Journal of the American Veterinary Medical Association·Leigh A LamontWilliam J Tranquilli
Aug 27, 2004·Journal of the American Veterinary Medical Association·Etienne CôtéNeil K Harpster
Sep 12, 2000·Current Cardiology Reports·M V SherridA Sharma
Sep 12, 2000·Current Cardiology Reports·D M Gilligan
Jan 6, 2001·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·T C Trujillo, P E Nolan
Sep 16, 2004·The American Journal of the Medical Sciences·Jon Brant McGregorMohammad Saeed
Jan 24, 2013·The American Journal of Cardiology·Edgar ArgulianMark V Sherrid
Jun 13, 2012·Progress in Cardiovascular Diseases·Michal Gajewski, Zak Hillel
Jun 13, 2012·Progress in Cardiovascular Diseases·Mark V Sherrid, Milla Arabadjian
Jun 13, 2012·Progress in Cardiovascular Diseases·Mark V Sherrid, Milla Arabadjian
Oct 29, 2011·Revista Portuguesa De Cardiologia : Orgão Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology·Bruno RodriguesOliveira Santos
Dec 4, 2010·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Sandeep JoshiMark V Sherrid
Dec 20, 2015·Pharmacotherapy·Nathan J Verlinden, James C Coons
May 19, 2009·La Presse médicale·Pierre Gibelin
Dec 3, 2008·International Journal of Cardiology·Piotr SzymańskiPiotr Hoffman
Oct 19, 2006·Progress in Cardiovascular Diseases·Mark V Sherrid
Apr 24, 2010·Congenital Heart Disease·Nicole A AbdyBrent J Barber
Nov 1, 2003·Journal of Veterinary Cardiology : the Official Journal of the European Society of Veterinary Cardiology·Philip R Fox
Jan 8, 2005·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Patrick MeimounChristophe Tribouilloy
Apr 17, 2014·Journal of cardiology·Mareomi HamadaYuji Shigematsu
Dec 19, 2006·Journal of the American College of Cardiology·Sherif F Nagueh, John J Mahmarian

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