Mechanism of carcinogenesis in familial tumors

International Journal of Clinical Oncology
Kazuo TamuraTakehira Yamamura

Abstract

It is thought that malignant tumors occur through interactions of multiple environmental factors and a personal genetic factor. A normal somatic cell having an intrinsic function is able to acquire the characteristics of a malignant cell under the influence of many factors. A small percentage of all tumors have obvious familial aggregation. These entities are called familial cancer. The familial cancer syndrome is well defined for colorectal cancer, breast cancer, endocrine neoplasia, and so on. Traits of familial tumors are sequentially inherited by offspring through gametes in a Mendelian fashion, most commonly in an autosomal-dominant manner. Carcinogenesis requires multiple genetic events. A patient with a familial tumor is ahead of an individual without any germline mutation in the carcinogenesis process. In such a situation, patients frequently suffer from multiple malignant tumors at a young age. It is well known that three major genes are closely related to the cell cycle and tumorigenesis. These gene types are protooncogenes, tumor suppressor genes, and DNA mismatch repair genes. Proto-oncogenes function to accelerate cells during the G1 or growth phase of the cell cycle. Tumor suppressor genes act as blocks against ce...Continue Reading

Citations

Oct 15, 2008·São Paulo Medical Journal = Revista Paulista De Medicina·Mariana Montenegro de Melo LiraJosé Vassallo
May 30, 2012·Oncology Reports·Takashi KunoNaohiro Tomita
Feb 9, 2020·International Journal of Molecular Sciences·Alejandro Cabrera-AndradeEduardo Tejera
Jul 6, 2019·International Journal of Clinical Oncology·Kazuo TamuraJunko Tatsumi-Miyajima

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