Mechanism of catch force: tethering of thick and thin filaments by twitchin.

Journal of Biomedicine & Biotechnology
T M Butler, M J Siegman

Abstract

Catch is a mechanical state occurring in some invertebrate smooth muscles characterized by high force maintenance and resistance to stretch during extremely slow relaxation. During catch, intracellular calcium is near basal concentration and myosin crossbridge cyctng rate is extremely slow. Catch force is relaxed by a protein kinase A-mediated phosphorylation of sites near the N- and C- temini of the minititin twitchin (approximately 526 kDa). Some catch force maintenance car also occur together with cycling myosin crossbridges at submaximal calcium concentrations, but not when the muscle is maximally activated. Additionally, the link responsible for catch can adjust during shortening of submaximally activated muscles and maintain catch force at the new shorter length. Twitchin binds to both thick and thin filaments, and the thin filament binding shown by both the N- and Cterminal portions of twitchin is decreased by phosphorylation of the sites that regulate catch. The data suggest that the twitchin molecule itself is the catch force beanng tether between thick and thin filaments. We present a model for the regulation of catch in which the twitchin tether can be displaced from thin filaments by both (a) the phosphorylation of ...Continue Reading

References

Sep 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·H F EpsteinH E Harris
Mar 16, 1979·Pflügers Archiv : European journal of physiology·R K Achazi
Jan 1, 1975·Pflügers Archiv : European journal of physiology·G Marchand-Dumont, F Baguet
Oct 1, 1976·The Journal of Cell Biology·R J LevineB Walcott
Jan 1, 1975·Blood Vessels·B Ljung, R Sivertsson
Sep 14, 1992·FEBS Letters·L Castellani, C Cohen
Jul 1, 1992·The American Journal of Physiology·T B VyasT M Butler
Jan 1, 1990·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·S Watabe, D J Hartshorne
Jan 1, 1989·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·S WatabeD J Hartshorne
Jan 1, 1989·Comparative Biochemistry and Physiology. A, Comparative Physiology·M FuruseJ Okumura
Nov 1, 1989·Clinical Physics and Physiological Measurement : an Official Journal of the Hospital Physicists' Association, Deutsche Gesellschaft Für Medizinische Physik and the European Federation of Organisations for Medical Physics·A MackieP Tothill
Jun 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·L Castellani, C Cohen
Dec 1, 1988·Journal of Muscle Research and Cell Motility·L CastellaniC Cohen
Jan 1, 1988·The American Journal of Physiology·C M Hai, R A Murphy
Jan 1, 1987·AORN Journal·B V Wetchler
May 1, 1986·American Journal of Obstetrics and Gynecology·M LandauerJ H Rankin
Oct 1, 1972·Comparative Biochemistry and Physiology. A, Comparative Physiology·R A Cole, B M Twarog
Dec 14, 1970·Journal of Molecular Biology·J Kendrick-JonesA G Szent-Györgyi
Mar 14, 1971·Journal of Molecular Biology·A G Szent-GyörgyiJ Kendrick-Jones
May 24, 1974·Pflügers Archiv : European journal of physiology·R K AchaziR Haakshorst
Dec 23, 1969·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·M J Kushmerick, R E Davies
Jan 1, 1973·Pflügers Archiv : European journal of physiology·F Baguet
Jan 1, 1971·Physiological Reviews·J C Rüegg
Jul 1, 1967·The Journal of General Physiology·B M Twarog
Mar 1, 1982·The Journal of Physiology·P D Evans, M V Siegler
Feb 1, 1980·Chest·J B GeeR Matthay
May 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·C Cohen
Nov 1, 1980·The Journal of General Physiology·M J SiegmanR E Davies
Jun 15, 1980·Developmental Biology·R H WaterstonS Brenner
Sep 1, 1994·Journal of Structural Biology·N Panté
Oct 1, 1994·Journal of Muscle Research and Cell Motility·V N KalabokisA G Szent-Györgyi
Aug 30, 1994·Proceedings of the National Academy of Sciences of the United States of America·W C ProbstK R Weiss

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Citations

Oct 8, 2015·Proceedings of the National Academy of Sciences of the United States of America·Guidenn SulbaránRoger Craig
Mar 21, 2012·Archives of Biochemistry and Biophysics·Stanislava V AvrovaYurii S Borovikov
Nov 10, 2011·Biophysical Journal·V S Senthil KumarCarolyn Cohen
Jul 16, 2014·PloS One·Nora TrammDavid Biron
Aug 6, 2016·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Marc ColeVasilis Z Marmarelis
Nov 5, 2016·Annual Review of Physiology·Stan Lindstedt, Kiisa Nishikawa
Jan 23, 2016·The Journal of Experimental Biology·Kiisa Nishikawa
Apr 29, 2015·PloS One·Oleg S MatusovskyNikolay S Shelud'ko
Feb 3, 2011·Journal of Muscle Research and Cell Motility·Thomas M Butler, Marion J Siegman
Jul 11, 2019·Journal of Muscle Research and Cell Motility·Kiisa NishikawaJenna A Monroy
Jun 1, 2018·Integrative and Comparative Biology·Kiisa C NishikawaUzma Tahir
Feb 25, 2017·Frontiers in Physiology·Anthony L HesselKiisa C Nishikawa

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Methods Mentioned

BETA
motility studies

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