Mechanism of chlorite degradation to chloride and dioxygen by the enzyme chlorite dismutase

Archives of Biochemistry and Biophysics
Irene SchaffnerChristian Obinger

Abstract

Heme b containing chlorite dismutase (Cld) catalyses the conversion of chlorite to chloride and dioxygen which includes an unusual OO bond formation. This review summarizes our knowledge about the interaction of chlorite with heme enzymes and introduces the biological role, phylogeny and structure of functional chlorite dismutases with differences in overall structure and subunit architecture. The paper sums up the available experimental and computational studies on chlorite degradation by water soluble porphyrin complexes as well as a model based on the active site of Cld. Finally, it reports the available biochemical and biophysical data of Clds from different organisms which allow the presentation of a general reaction mechanism. It includes binding of chlorite to ferric Cld followed by subsequent heterolytic OCl bond cleavage leading to the formation of Compound I and hypochlorite, which finally recombine for production of chloride and O2. The role of the Cld-typical distal arginine in catalysis is discussed together with the pH dependence of the reaction and the role of transiently produced hypochlorite in irreversible inactivation of the enzyme.

References

Feb 21, 2009·FEMS Microbiology Letters·Farrakh MehboobServé W M Kengen
Dec 18, 2012·Dalton Transactions : an International Journal of Inorganic Chemistry·Beatrice BlancJennifer L DuBois
Oct 29, 2013·Dalton Transactions : an International Journal of Inorganic Chemistry·Shuo SunShi-Lu Chen
Mar 18, 2015·Archives of Biochemistry and Biophysics·Arianna I Celis, Jennifer L DuBois

❮ Previous
Next ❯

Citations

Sep 7, 2016·Biochemistry·Stefan HofbauerChristian Obinger
Jan 10, 2018·Frontiers in Microbiology·Kellen C MobiliaJulie L Zilles
Oct 26, 2018·Frontiers in Microbiology·Gloria Ngozi Okpala, Gerrit Voordouw
Oct 29, 2020·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Durga MahorPeter-Leon Hagedoorn
Sep 7, 2020·Biochimica Et Biophysica Acta. Proteins and Proteomics·Stefan HofbauerPaul G Furtmüller
Feb 7, 2018·Biochemistry·Zachary GeeraertsGudrun S Lukat-Rodgers
Dec 30, 2017·Chemical Reviews·Xiongyi Huang, John T Groves
Oct 11, 2017·Chemical Reviews·Regina A BagliaDavid P Goldberg
Oct 5, 2021·Acta Crystallographica. Section D, Structural Biology·Gabriela C Schröder, Flora Meilleur

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.