PMID: 6167651Jul 1, 1981Paper

Mechanism of chlorpromazine-induced arrhythmia -- arrhythmia and mitochondrial dysfunction

Journal of Electrocardiology
M KitazawaK Kotaka

Abstract

In this study, we investigated the mechanism of the arrhythmogenic action of chlorpromazine (CPZ). Thirty-two anesthetized mongrel dogs were used. In each, the chest was opened and a stimulating electrode was attached to the apex of the left ventricle and the ventricular multiple response threshold (VMRT) was measured. The carotid artery was cannulated to measure aortic pressure. The dogs were divided into four groups, and the time course of VMRT, blood pressure, and heart rate were determined. All groups were placed under observation for 30 min after CPZ infusion. In the control group, only saline (2ml/kg) was infused; CPZ group: CPZ (Img/kg) was infused 10 min after saline (2ml/kg) infusion; CoQ10 group: Coenzyme Q10 (CoQ10) (5mg/kg) was infused 10 min before CPZ (Img/kg) infusion; FAD group: Flavin-adenine-dinucleotide (FAD) (2mg/kg) was infused 10 min before CPZ (Img/kg) infusion. In each group, myocardial mitochondria were prepared 30 min after CPZ infusion. The mitochondrial functions, respiratory control index, AdP/O, State III rate of oxygen consumption, and activities of two segments of the electron-transport chain (NADH leads to CoQ leads to cyt.c and cyt.c leads to cyt.a,a3 leads to O2) were measured separately. Ca++...Continue Reading

References

Feb 1, 1976·The American Journal of Cardiology·N O FowlerI B Hanenson
Feb 1, 1968·Journal of Biochemistry·T Matsubara, B Hagihara
Jun 21, 1965·JAMA : the Journal of the American Medical Association·L E HOLLISTER, J C KOSEK

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Citations

Jan 1, 1987·Journal of Clinical Pharmacology·C M Lathers, L J Lipka
Jun 1, 1986·Asia-Oceania Journal of Obstetrics and Gynaecology·T HataM Kitao
Jan 1, 1982·Journal of Electrocardiology·S SugiyamaT Ozawa

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