Mechanism of cigarette smoke-induced kinin B(1) receptor expression in rat airways

Peptides
James Chi-Jen LinAndré Morin

Abstract

Pulmonary inflammation is an important pathological feature of tobacco smoke related lung diseases such as chronic obstructive pulmonary disease (COPD). Kinin type 1 and type 2 receptors (B(1)R, B(2)R) are known to be associated with inflammatory responses of the lungs and other organs. In this study, we investigated whether cigarette smoke-induced airway inflammation could up-regulate B(1)R and B(2)R in correlation with IL-1β and TNF-α. Rat lung slices treated with 5 μg/ml total particulate matter (TPM) of cigarette smoke for 24 h showed an enhanced expression of B(1)R and IL-1β by 5-fold and 30-fold, respectively, in comparison to vehicle treatment (dimethyl sulfoxide). However, higher concentrations of TPM failed to induce B(1)R. No significant increase of B(2)R or TNF-α gene induction was observed. IL-1 receptor antagonist (IL-1Ra, 2 ng/ml) significantly blocked B(1)R gene induction by TPM, while 500 μM pentoxifylline, TNF-α inhibitor, reduced it partially. Western blot analysis showed a 2-fold enhanced expression of B(1)R in rat lung slices treated with 5 μg/ml TPM for 24 h and such protein expression was totally blocked by a co-treatment with IL-1Ra but not with pentoxifylline. In addition to the lower airways, rat trache...Continue Reading

References

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Citations

Jan 24, 2012·Journal of Neuroinflammation·Sébastien TalbotRéjean Couture
Sep 14, 2012·Journal of Neuroinflammation·Sébastien TalbotRéjean Couture
May 24, 2011·Pulmonary Pharmacology & Therapeutics·Michael J Sanderson
Mar 23, 2011·Experimental Eye Research·Mylène PouliotElvire Vaucher
Feb 23, 2013·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Yaping ZhangCang-Bao Xu
Dec 14, 2011·Experimental Neurology·Sébastien Talbot, Réjean Couture
Dec 12, 2012·Behavioural Brain Research·H De Brito GariepyR Couture
Apr 10, 2016·British Journal of Pharmacology·Youssef Haddad, Réjean Couture
Nov 17, 2016·Molecular Neurobiology·Natália Fontana NicolettiFernanda Bueno Morrone
Nov 23, 2017·International Journal of Molecular Sciences·Adil El MidaouiRéjean Couture
Aug 22, 2017·Frontiers in Pharmacology·Youssef Haddad, Réjean Couture
Dec 30, 2017·British Journal of Pharmacology·Soumaya HachanaElvire Vaucher
Aug 6, 2021·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Jose Manuel Martinez ManzanoGabriel Patarroyo-Aponte

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