Mechanism of citrinin-induced dysfunction of mitochondria. II. Effect on respiration, enzyme activities, and membrane potential of liver mitochondria

Cell Biochemistry and Function
G M ChagasM L Klüppel

Abstract

The mycotoxin citrinin, depressed the phosphorylation efficiency of liver mitochondria as deduced from a decrease of respiratory coefficient and of the ADP/O ratio. Citrinin (1.0 mM) inhibited some enzymes linked to the respiratory chain, namely NADH oxidase and NADH cytochrome c reductase involved with complex I. The activities of enzymes related with other enzymatic complexes of the respiratory chain were either unaffected or enhanced. ATPase activity was inhibited by the mycotoxin. Malate, glutamate, and 2-oxoglutarate dehydrogenases were also inhibited. The transmembrane potential (delta psi), developed by energized mitochondria and depolarization on the addition of ADP, was decreased. The results suggest that citrinin promotes a partial dissipation of the transmembrane potential, different from that resulting from a classical uncoupler such as 2,4-dinitrophenol.

References

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Citations

Nov 27, 2007·Applied Microbiology and Biotechnology·Yii-Lih LinNan-Wei Su
Mar 8, 2016·Food Chemistry·Massimiliano MagroFabio Vianello
Jan 12, 2016·Toxicon : Official Journal of the International Society on Toxinology·Gábor PappMiklós Pesti
Mar 1, 1995·Cell Biochemistry and Function·G M ChagasM L Klüppel
Dec 1, 1995·Cell Biochemistry and Function·G M ChagasB M Oliveira
Jul 16, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ágnes BlaskóMiklós Pesti
Feb 9, 2002·Cell Biochemistry and Function·Eneida Janiscki Da LozzoEva Gunilla Skare Carnieri
Dec 11, 2007·International Journal of Toxicology·D A Rendon
Sep 5, 2018·IUBMB Life·Muhammad Torequl IslamAna Amélia de Carvalho Melo-Cavalcante
Jul 16, 2010·Journal of Food Science·Chun-Hsien LeeTzu-Ming Pan
Mar 11, 2016·The Journal of Toxicological Sciences·Yui NakajimaYo Shinoda

Related Concepts

Citrinin
Energy Metabolism
Enzyme Activation
Resting Potentials
Mitochondria, Liver
Oxygen Consumption
Protons

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