Mechanism of complement-induced stimulation of prostacyclin production by isolated rabbit peritoneum

Prostaglandins
M RampartA G Herman

Abstract

The interaction between the complement system and prostaglandin synthesis has not thoroughly been explored, although both mediators are known to be involved in inflammatory reactions and endotoxic shock. When rabbit peritoneum, a rich source of prostacyclin forming activity was incubated in serum in which the complement system was activated (CVF, LPS, zymosan), the tissue produced significantly more PGI2, when compared with appropriate controls, indicating that by activation of the complement, factors were generated that stimulated PGI2 biosynthesis. Further results indicated that tryptic cleavage products of complement factor C3 and C5 also led to the appearance of PGI2 releasing principles with a molecular weight of about 7000-11000. The stimulation of PGI2 biosynthesis was explained by enhanced release of AA, and not due to increased activity of cyclo-oxygenase or PGI2 synthetase. Our results suggest that complement-derived products may promote the supply of prostaglandins at the site of inflammation.

References

Jan 1, 1978·Advances in Immunology·T E Hugli, H J Müller-Eberhard
Sep 1, 1977·Inflammation·R J Ulevitch, C G Cochrane
Dec 20, 1973·Biochimica Et Biophysica Acta·D H Nugteren, E Hazelhof
Sep 1, 1965·Immunochemistry·G ManciniJ F Heremans
Nov 1, 1980·The Journal of Pharmacy and Pharmacology·N P StimlerT E Hugli
Apr 11, 1980·European Journal of Pharmacology·H BultA G Herman

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Citations

Mar 1, 1983·Naunyn-Schmiedeberg's Archives of Pharmacology·M RampartA G Herman
Jan 1, 1986·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·Y LouagieR Ponlot
Aug 1, 1983·Agents and Actions·H Bult, A G Herman
Feb 1, 1985·British Journal of Pharmacology·H BultM Rampart
Sep 1, 1983·Biochemical Pharmacology·H Bult, A G Herman

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