PMID: 2484616Jul 1, 1989Paper

Mechanism of comutagenesis of sodium arsenite with n-methyl-n-nitrosourea

Biological Trace Element Research
J H Li, T G Rossman

Abstract

Arsenic compounds are known carcinogens. Although many carcinogens are also mutagens, we have previously shown that sodium arsenite is not mutagenic at either the Na+/K+ ATPase or hprt locus in Chinese hamster V79 cells. It can, however, enhance UV-mutagenesis. We now confirm the nonmutagenicity of sodium arsenite in line G12, a pSV2gpt-transformed V79 (hprt-) cell line, which is able to detect multilocus deletions in addition to point mutations and small deletions. The lack of arsenic mutagenicity has led to studies emphasizing its comutagenicity. Sodium arsenite at relatively nontoxic concentrations (5 microM for 24 h or 10 microM for 3 h) is comutagenic with N-methyl-N-nitrosourea (MMU) at the hprt locus in V79 cells. Using a nick translation assay, which measures DNA strand breaks by incorporating radioactive deoxyribonucleoside monophosphate at their 3'OH ends in permeabilized cells, we found that much more incorporation was seen in cells treated with MNU (4 mM, 15 min) followed by 3-h incubation with 10 microM sodium arsenite compared with cells exposed to the same MNU treatment followed by 3-h incubation without sodium arsenite. This result shows that in the presence of arsenite, strand breaks resulting from MNU or its r...Continue Reading

References

Dec 1, 1979·Archives of Biochemistry and Biophysics·A Weissbach
Jan 1, 1985·Environmental Mutagenesis·R D Snyder, D W Matheson
Nov 1, 1972·Mutation Research·G R Paton, A C Allison
Mar 18, 1982·Nature·D Creissen, S Shall
Jan 1, 1982·Annual Review of Biochemistry·T Lindahl
Jan 1, 1980·Environmental Mutagenesis·T G RossmanW Troll
Feb 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·B Singer, T P Brent
Jan 1, 1980·Mutation Research·A Léonard, R R Lauwerys
Mar 1, 1979·Biological Trace Element Research·F W Sunderman

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Citations

Feb 6, 2007·International Archives of Occupational and Environmental Health·D LewińskaR Nilsson
Dec 16, 1992·Mutation Research·A N JhaA T Natarajan
May 1, 1990·Mutation Research·A HartwigD Beyersmann
Dec 1, 1992·Mutation Research·N K Roy, T G Rossman
Dec 4, 2003·Mutation Research·Toby G Rossman
Jun 22, 2005·Toxicology and Applied Pharmacology·Jack C NgMichael R Moore
Feb 4, 1998·Chemico-biological Interactions·T Gebel
Jan 22, 1998·Mutation Research·A M SalazarE Rojas
Jun 22, 2002·Toxicology Letters·Huu-Phuc TranJack C Ng
Jul 20, 2001·Free Radical Biology & Medicine·T S WangK Y Jan
Aug 23, 2001·Mutation Research·F I AbdullaevJ J Espinosa-Aguirre
May 30, 2002·Mutation Research·Andrew MaierAlvaro Puga
Jun 1, 1997·Mutation Research·M M MooreC L Doerr
Jul 23, 1999·Mutation Research·E RojasP Ostrosky-Wegman
Jul 19, 2011·Metallomics : Integrated Biometal Science·Erika MitchellBibudhendra Sarkar
Sep 6, 2006·Journal of Toxicology and Environmental Health. Part a·Jadwiga PalusMaciej Stepnik
Jul 14, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Michael F HughesDavid J Thomas
Apr 1, 1990·Endodontics & Dental Traumatology·T Sotokawa
Mar 21, 2013·Molecular Cancer·Roland HubauxVictor D Martinez
Nov 12, 2002·Environmental Health Perspectives·Toby G RossmanMaarten C Bosland
Aug 10, 2007·Environmental Health Perspectives·Katie M ApplebaumHeather H Nelson
Aug 28, 1999·Environmental Health Perspectives·P KurttioJ Pekkanen
Apr 9, 2008·Journal of Clinical Biochemistry and Nutrition·Sutapa MukherjeeRathindra K Bhattacharya
Nov 26, 2013·Mutation Research. Fundamental and Molecular Mechanisms of Mutagenesis·Fusao HirataAiko Hirata
Mar 1, 2012·Archives of Pharmacal Research·Yuri ChoDae Kyong Kim
Feb 25, 2009·Critical Reviews in Toxicology·Ulrike Schuhmacher-WolzKlaus Schneider
Aug 6, 2015·Biological Trace Element Research·Munesh KumarRajesh Thakur
May 10, 2005·Environmental and Molecular Mutagenesis·Jadwiga PalusRobert Nilsson
Jan 15, 2013·Environment International·Pritha BhattacharjeeAshok K Giri

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