Mechanism of Cu+-transporting ATPases: soluble Cu+ chaperones directly transfer Cu+ to transmembrane transport sites.

Proceedings of the National Academy of Sciences of the United States of America
Manuel González-Guerrero, José M Argüello

Abstract

As in other P-type ATPases, metal binding to transmembrane metal-binding sites (TM-MBS) in Cu(+)-ATPases is required for enzyme phosphorylation and subsequent transport. However, Cu(+) does not access Cu(+)-ATPases in a free (hydrated) form but is bound to a chaperone protein. Cu(+) transfer from Cu(+) chaperones to regulatory cytoplasmic metal-binding domains (MBDs) present in these ATPases has been described, but there is no evidence of a proposed subsequent Cu(+) movement from the MBDs to the TM-MBS. Alternatively, we postulate the parsimonious Cu(+) transfer by the chaperone directly to TM-MBS. Testing both models, the delivery of Cu(+) by Archaeoglobus fulgidus Cu(+) chaperone CopZ to the corresponding Cu(+)-ATPase, CopA, was studied. As expected, CopZ interacted with and delivered the metal to CopA MBDs. Cu(+)-loaded MBDs, acting as metal donors, were unable to activate CopA or a truncated CopA lacking MBDs. Conversely, Cu(+)-loaded CopZ activated the CopA ATPase and CopA constructs in which MBDs were rendered unable to bind Cu(+). Furthermore, under nonturnover conditions, CopZ transferred Cu(+) to the TM-MBS of a CopA lacking MBDs. These data are consistent with a model where MBDs serve a regulatory function without par...Continue Reading

References

Nov 15, 1979·Analytical Biochemistry·P A LanzettaO A Candia
Mar 20, 1995·Analytical Biochemistry·A J Brenner, E D Harris
Mar 7, 1998·Journal of Molecular Evolution·K B Axelsen, M G Palmgren
Nov 11, 1999·Biochimica Et Biophysica Acta·P Y JensenO Farver
Nov 11, 1999·Proceedings of the National Academy of Sciences of the United States of America·I HamzaJ D Gitlin
Apr 15, 2000·The Journal of Biological Chemistry·D L Huffman, T V O'Halloran
May 19, 2000·The Journal of Biological Chemistry·T V O'Halloran, V C Culotta
Aug 31, 2000·Nature Structural Biology·A K WernimontA C Rosenzweig
Oct 26, 2001·The Journal of Biological Chemistry·Ruslan TsivkovskiiSvetlana Lutsenko
Dec 19, 2001·Biochemistry·L BanciF J Ruiz-Dueñas
Jan 5, 2002·The Journal of Biological Chemistry·Atin K MandalJosé M Argüello
Jun 5, 2002·Annual Review of Biochemistry·Jack H Kaplan
Aug 9, 2002·Nature·Chikashi Toyoshima, Hiromi Nomura
Sep 28, 2002·The Journal of Biological Chemistry·Bin Fan, Barry P Rosen
Jan 24, 2003·Journal of Bioenergetics and Biomembranes·Diane W Cox, Steven D P Moore
Jul 24, 2003·The Journal of Biological Chemistry·Sebasián Mana-CapelliJosé M Argüello
Sep 6, 2003·Science·Anita ChangelaAlfonso Mondragón
Sep 17, 2003·Biochemistry·Atin K Mandal, José M Argüello
Nov 25, 2003·FEBS Letters·Chikashi ToyoshimaYuji Sugita
Dec 25, 2003·The Journal of Membrane Biology·J M Argüello
Jan 8, 2004·The Journal of Biological Chemistry·Amy K WernimontAmy C Rosenzweig
May 15, 2004·The Biochemical Journal·Peep PalumaaRannar Sillard
Jun 11, 2004·Annual Review of Biochemistry·Chikashi Toyoshima, Giuseppe Inesi
Oct 21, 2004·The Journal of Biological Chemistry·Atin K MandalJosé M Argüello
Feb 24, 2006·The Journal of Biological Chemistry·Matthew H SazinskyAmy C Rosenzweig
Mar 31, 2006·Proceedings of the National Academy of Sciences of the United States of America·David AchilaDavid L Huffman
Oct 27, 2006·Biochimica Et Biophysica Acta·Ying YangJosé M Argüello
Jan 16, 2007·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·José M ArgüelloManuel González-Guerrero
Jan 19, 2007·The Journal of Biological Chemistry·Liliya A Yatsunyk, Amy C Rosenzweig
Jul 5, 2007·The Journal of Biological Chemistry·Matthew H SazinskyAmy C Rosenzweig
Jul 7, 2007·Physiological Reviews·Svetlana LutsenkoOleg Y Dmitriev

❮ Previous
Next ❯

Citations

Oct 18, 2011·Biochemistry·José M ArgüelloDaniel Raimunda
Oct 1, 2009·Chemical Reviews·Zhen MaDavid P Giedroc
Oct 15, 2009·Chemical Reviews·Amie K Boal, Amy C Rosenzweig
May 15, 2012·Journal of the American Chemical Society·Aaron M KellerPeng Chen
Sep 15, 2009·Nature Structural & Molecular Biology·Min LuDax Fu
Jul 23, 2011·Proceedings of the National Academy of Sciences of the United States of America·Adriana Badarau, Christopher Dennison
Dec 27, 2011·Proceedings of the National Academy of Sciences of the United States of America·Steve TotteyNigel J Robinson
Jun 16, 2009·The Journal of Biological Chemistry·Manuel González-GuerreroJosé M Argüello
Nov 6, 2009·The Journal of Biological Chemistry·Yan Zhang, Vadim N Gladyshev
Apr 7, 2010·The Journal of Biological Chemistry·Bahia Khalfaoui HassaniSoufian Ouchane
Nov 28, 2012·The Journal of Biological Chemistry·Teresita Padilla-BenavidesJosé M Argüello
Sep 6, 2008·The Journal of Biological Chemistry·Manuel González-GuerreroJosé M Argüello
Jul 16, 2009·The Journal of Biological Chemistry·Jack H Kaplan, Svetlana Lutsenko
Dec 20, 2012·Antioxidants & Redox Signaling·Yuta Hatori, Svetlana Lutsenko
Oct 16, 2012·Journal of Bacteriology·Yukari MaezatoPaul Blum
Apr 2, 2011·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Oleg Y Dmitriev
Mar 9, 2010·Annual Review of Biochemistry·Nigel J Robinson, Dennis R Winge
Jan 26, 2013·PLoS Computational Biology·W Lee PangNitin S Baliga
May 11, 2010·Future Medicinal Chemistry·Arnab Gupta, Svetlana Lutsenko
Aug 19, 2014·Nature·Kaituo WangPontus Gourdon
Mar 1, 2011·Annual Review of Biophysics·Michael G Palmgren, Poul Nissen
Jun 7, 2014·Applied Microbiology and Biotechnology·Medhat RehanLouis S Tisa
Jun 10, 2011·Journal of Cell Communication and Signaling·Giuseppe Inesi
Jan 9, 2009·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Nicholas A VeldhuisJames Camakaris
Jan 7, 2011·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Daniel RaimundaJosé M Argüello
Nov 13, 2009·Nutrition Reviews·Peter V E van den Berghe, Leo W J Klomp
Jan 29, 2013·Nature Chemical Biology·Yue FuDavid P Giedroc
Mar 25, 2010·Cellular and Molecular Life Sciences : CMLS·Lucia BanciSimone Ciofi-Baffoni
Oct 24, 2009·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Amanda N BarrySvetlana Lutsenko
Jan 9, 2016·Biomolecular Concepts·Maria Matson DzeboPernilla Wittung-Stafshede
Dec 4, 2014·Proceedings of the National Academy of Sciences of the United States of America·Crysten E Blaby-HaasSabeeha S Merchant
Jan 23, 2016·Frontiers in Plant Science·Guadalupe Aguirre, Marinus Pilon
Mar 19, 2013·Journal of Molecular Biology·Daniel MattlePoul Nissen
May 28, 2015·Scientific Reports·Moritz S NiemiecPernilla Wittung-Stafshede
Jun 23, 2009·Molecular Microbiology·Lucas B Pontel, Fernando C Soncini
May 1, 2009·The New Phytologist·Jason L BurkheadMarinus Pilon
May 30, 2009·The EMBO Journal·Takeo Tsuda, Chikashi Toyoshima
May 18, 2012·Molecular Microbiology·Daniel RaimundaJosé M Argüello

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Biological Chemistry
Manuel González-GuerreroJosé M Argüello
Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
José M ArgüelloManuel González-Guerrero
Proceedings of the National Academy of Sciences of the United States of America
David AchilaDavid L Huffman
© 2022 Meta ULC. All rights reserved