PMID: 9419743Jan 1, 1994Paper

Mechanism of cytokine stimulation of prostaglandin biosynthesis in human decidua

Journal of the Society for Gynecologic Investigation
J K PollardM D Mitchell

Abstract

The purpose of this study was to determine the mechanism of action of the cytokines tumor necrosis factor-alpha (TNF alpha) and interleukin-1 beta (IL-1 beta) on the stimulation of prostaglandin (PG) production in human decidua. Decidual cells from term placentas were grown in culture until confluent. Incubations were performed with TNF alpha or IL-1 beta, and with cycloheximide, actinomycin D, arachidonic acid, or acetylsalicylic acid (ASA). Prostaglandin E2 was measured by radioimmunoassay and cellular protein determined. The concentration-related stimulation of decidual PGE2 production by IL-1 beta and TNF alpha was completely abrogated by cycloheximide and actinomycin D treatment. Although arachidonic acid alone stimulated decidual PGE2 biosynthesis, the addition of IL-1 beta or TNF alpha consistently augmented this effect. Both cytokines induced recovery of PGE2 biosynthesis from ASA pretreatment more rapidly than controls. Interleukin-1 beta and TNF alpha both act on decidual PG biosynthesis in a manner requiring new protein synthesis. In combination with our other results, this suggests that IL-1 beta and TNF alpha act to induce PG endoperoxide synthase activity.

References

Aug 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·T Hla, K Neilson
Jun 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·M K O'BanionD A Young
Apr 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·W L XieD L Simmons
Jan 1, 1990·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·F BreviarioE Dejana
Sep 1, 1990·Prostaglandins, Leukotrienes, and Essential Fatty Acids·M D MitchellR J Romero
Sep 1, 1989·Prostaglandins, Leukotrienes, and Essential Fatty Acids·R RomeroM D Mitchell
May 1, 1989·American Journal of Obstetrics and Gynecology·R RomeroS K Durum
Mar 1, 1987·American Journal of Obstetrics and Gynecology·P R BennettM G Elder
May 1, 1988·American Journal of Obstetrics and Gynecology·R RomeroJ C Hobbins
Aug 1, 1984·American Journal of Obstetrics and Gynecology·C HameedF Archbald

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Citations

Aug 2, 2008·Reproduction, Fertility, and Development·Rosário P Roberto da CostaGraça Ferreira-Dias
Aug 20, 2019·Basic & Clinical Pharmacology & Toxicology·Katrina M Mirabito ColafellaJorie Versmissen
Jun 22, 2012·Mediators of Inflammation·Lynne SykesPhillip R Bennett
Feb 6, 2021·Journal of Reproductive Immunology·Sanja LöbTheresa Vilsmaier
May 8, 2002·Prostaglandins, Leukotrienes, and Essential Fatty Acids·K W Marvin, M D Mitchell
May 17, 2005·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Jacek R Wilczyński

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