Mechanism of decreased baroreceptor activity in chronic hypertensive rabbits. Role of endogenous prostanoids

The Journal of Clinical Investigation
P L XieF M Abboud

Abstract

We examined the contribution of endogenous prostanoids to baroreceptor activation in chronic renal hypertension. Baroreceptor activity was recorded from the vascularly isolated carotid sinus during slow ramp increases in pressure in rabbits anesthetized with pentothal and chloralose. Mean arterial pressure averaged 133 +/- 4 mmHg in hypertensive rabbits (one kidney, one wrap, n = 12) and 85 +/- 3 mmHg in normotensive rabbits (one kidney, no wrap, n = 13). Baroreceptor activity was decreased significantly (P less than 0.05) in the hypertensive compared with the normotensive rabbits. The decreased baroreceptor activity could not be explained by decreased distensibility of the carotid sinus (sonomicrometers). Inhibition of the endogenous formation of prostanoids with intrasinus administration of indomethacin (50 microM) decreased baroreceptor activity in normotensive (P less than 0.05) but not in hypertensive rabbits over a wide range of pressures. At a pressure of 120 mmHg, activity declined from 61 +/- 14 spikes/s before indomethacin to 47 +/- 12 spikes/s with indomethacin, i.e., a drop of 24 +/- 4%. In contrast, corresponding values in hypertensive rabbits averaged 41 +/- 13 and 40 +/- 12 spikes/s (-1 +/- 2%). Intrasinus prosta...Continue Reading

References

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Citations

Jan 20, 1995·Journal of the Autonomic Nervous System·Z Li, M W Chapleau
Feb 20, 2013·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·J S WuC J Chang
Jan 1, 1991·Clinical and Experimental Hypertension. Part A, Theory and Practice·M W ChapleauF M Abboud
May 5, 2007·The Journal of Physiology·Vladislav SnitsarevFrançois M Abboud
Feb 26, 2014·Autonomic Neuroscience : Basic & Clinical·Valter J Santana-FilhoMark W Chapleau
Mar 13, 2014·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Philip Thomas, Indranil Dasgupta
Jan 29, 2017·Expert Opinion on Pharmacotherapy·Yogita RochlaniWilbert S Aronow
Apr 2, 2010·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Aggeliki P PolitiDimitris Th Kremastinos
Aug 3, 2005·Hypertension·Vladislav SnitsarevFrancois M Abboud
Aug 1, 1995·Hypertension·M W ChapleauF M Abboud
Feb 1, 1992·Circulation·R J ParmerR A Stone
Jul 1, 1993·Hypertension·R D ManningM W Norton
Oct 18, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Maria Cristina O SalgadoHelio C Salgado
Oct 23, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Marty D SprangerDonal S O'Leary
Dec 23, 2004·Journal of Cardiovascular Pharmacology·Markus BéchirGeorg Noll
Oct 16, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Kevin D Monahan, Chester A Ray
Jan 1, 1995·Clinical and Experimental Hypertension : CHE·M W ChapleauF M Abboud
Jul 19, 2001·Annals of the New York Academy of Sciences·M W ChapleauF M Abboud
Mar 29, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M VitelaS W Mifflin

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