PMID: 1211481Dec 1, 1975Paper

Mechanism of diuretic response associated with atrial tachycardia

The American Journal of Physiology
J BoykinR W Schrier

Abstract

Left atrial pacing was performed in three groups of anesthetized dogs. In the first group of eight intact dogs a mean increase in atrial rate (AR) from 140 +/- 7 to 244 +/- 6 was associated with a decrease in urinary osmolality (U osmol) from 631 +/- 72 to 264 +/- 43 mosmol/kg (P less than .001), and free-water clearance (CH20) increased from -.325 +/- .06 to +.355 +/- .15 ml/min (P less than .001). At the same time left atrial pressure (LAP) increased from 6 +/- 1 to 15 +/- 1 mmHg (P less than .001). A second group of studies was performed in six hypophysectomized, steroid-replaced animals receiving 40-50 muU/kg per min of antidiuretic hormone (ADH). In these animals AR was increased from 148 +/- 17 to 250 +/- 17 but diuresis did not occur. In these studies Uosmol was 690 +/- 55 before and 704 +/- 49 mosmol/kg after atrial pacing and CH20 also did not change. Left atrial pressure increased from 10 +/- 2 to 19 +/- 2 mmHg during atrial pacing. A third group of studies was performed in five animals with bilateral cervical vagotomy. In these animals AR was increased from 159 +/- 6 to 258 +/- 17 and LAP increased from 7 +/- 1 to 16 +/- 2 mmHg. Osmolality increased from 808 +/- 72 to 1,049 +/- 65 musmol/kg (P less than .005) and CH2...Continue Reading

Citations

Oct 6, 1984·British Medical Journal·R Canepa-AnsonR Sutton
Jun 5, 1998·Clinical and Experimental Pharmacology & Physiology·H YonedaK Naito
Dec 16, 1982·The New England Journal of Medicine·D G BichetR W Schrier
Jun 6, 2009·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Sevasti-Maria ChaldoupiPeter Loh
Dec 26, 2003·Circulation Journal : Official Journal of the Japanese Circulation Society·Takashi NozawaKatsusuke Yano
Jan 1, 1981·The American Journal of Medicine·K L Skorecki, B M Brenner
Aug 1, 1989·Baillière's Clinical Endocrinology and Metabolism·A W Cowley, R J Roman

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