Mechanism of enhanced antigen presentation by B cells activated with anti-mu plus interferon-gamma: role of B7-2 in the activation of naive and memory CD4+ T cells

European Journal of Immunology
T MorokataH Nariuchi

Abstract

B cells activated with anti-mu antibody plus interferon (IFN)-gamma exerted strong antigen presentation activity for T cell proliferation. The enhanced antigen presentation function was shown to be due to the increase in B7-2 expression. When B cells were stimulated with anti-mu, expression of MHC major histocompatibility complex class II, heat-stable antigen (HSA), ICAM-1 and B7-2 was increased. The presence of IFN-gamma further augmented the expression of B7-2 on anti-mu-stimulated B cells. B7-1 was not expressed on B cells under these conditions. The participation of B7-2 in the elicitation of the proliferative response of T cells was confirmed by the inclusion of anti-B7-2 antibody in cultures. The enhanced expression of either HSA or ICAM-1 was shown not to play a major role in the increased B cell antigen presentation capacity. The major T cell population responding to this activated B cell antigen presentation was shown to be CD44low naive CD4+ T cells, whereas CD45RBlow memory CD4+ T cells responded only weakly. The difference in proliferative responses between naive and memory CD4+ T cells was explained by the different efficiency in IL-2 production of these cell populations in response to antigen presentation by B cel...Continue Reading

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Citations

Sep 24, 2002·Nature Immunology·Akanksha ChaturvediKanury V S Rao
Jul 6, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·D J KasprowiczV M Sanders
Apr 25, 2018·Nature Communications·Cristian Gabriel BeccariaAdriana Gruppi
May 8, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Joseph R Podojil, Virginia M Sanders

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