PMID: 6989756Jan 1, 1980Paper

Mechanism of enhanced blood pressure rise after reclipping following removal of a renal artery clip in rats

Hypertension
R ten Berg, W de Jong

Abstract

The effect of removing a renal artery clip 14 to 18 days after its application was studied in two-kidney, one clip hypertensive rats. Blood pressure decreased to a normotensive level within 24 hours after the removal of the clip. The cardiovascular effects of reapplication of the clip and infusion of renin, angiotensin II, and norepinephrine were assessed at that time. Reapplication of the clip to the unclipped renal artery was followed in 1 hour by an increase in blood pressure to the level of sham-operated renal hypertensive rats. After reapplication of the clip, plasma renin activity increased to the same level as after the initial application. Application of the clip to the contralateral renal artery did not affect blood pressure and failed to increase plasma renin activity. It appears that renin release is a prerequisite for the rapid rise of blood pressure after reapplication of the clip. The infusion of renin, angiotensin II, and norepinephrine for 90 minutes caused an enhanced blood pressure response similar to that observed following reapplication of the clip. The increase in blood pressure in control rats was associated with bradycardia, which was absent in unclipped rats. The enhanced response of unclipped rats to an...Continue Reading

References

Jun 5, 1976·Lancet·J J BrownP Trust
Oct 1, 1979·British Journal of Clinical Pharmacology·A M CummingsJ I Robertson
Jun 12, 1979·Pflügers Archiv : European journal of physiology·R G ten Berg, W de Jong
Jun 1, 1975·The American Journal of Physiology·J MöhringS Kazda
Jan 1, 1972·Naunyn-Schmiedeberg's Archives of Pharmacology·G Haeusler, L Finch
Dec 1, 1964·The Biochemical Journal·J J BrownM Tree
May 1, 1967·The Journal of Physiology·C J Dickinson, R Yu
Feb 1, 1974·Clinical Science and Molecular Medicine·J Deheneffe, A Bernard
Dec 1, 1973·The American Journal of Physiology·F H LeenenD de Wied
Oct 1, 1969·Proceedings of the Society for Experimental Biology and Medicine·W De JongA Witter
Feb 1, 1970·The American Journal of Physiology·E M Krieger
Jul 1, 1971·Journal of Applied Physiology·F H Leenen, W de Jong
Jan 1, 1969·Proceedings of the Society for Experimental Biology and Medicine·W de Jong
Sep 10, 1964·The New England Journal of Medicine·N M KAPLAN, J G SILAH
Apr 1, 1947·Proceedings of the Society for Experimental Biology and Medicine·R E SHIPLEY, J H TILDEN

❮ Previous
Next ❯

Citations

May 1, 1983·Clinical and Experimental Pharmacology & Physiology·J D SwalesH Thurston
Feb 1, 1996·Clinical and Experimental Pharmacology & Physiology·M G Melaragno, G D Fink
Feb 1, 1995·Hypertension·M G Melaragno, G D Fink
Oct 20, 2018·Nature Reviews. Nephrology·Alan Kim Johnson, Baojian Xue
Aug 21, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Alan Kim JohnsonBaojian Xue
Jan 10, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Noreen F RossiMaria Maliszewska-Scislo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bradyarrhythmias

Bradyarrhythmias are slow heart rates. Symptoms may include syncope, dizziness, fatigure, shortness of breath, and chest pains. Find the latest research on bradyarrhythmias here.