Mechanism of exercise-induced augmentation of lymphokine activated killer (LAK) cell activity in the horse

Veterinary Immunology and Immunopathology
D W HorohovP A Melrose

Abstract

Intense exercise affects various parameters of the immune system. The overall effect of exercise on immune function is dependent upon the physical condition of the subject, the intensity and duration of the exercise period, and the immune parameter assessed. Unconditioned horses subjected to a single bout of intensive exercise exhibit multiple alterations in immune function, including an augmentation of lymphokine activated killer (LAK) cell function. This increase in LAK cell activity is not due to an increase in circulating LAK precursors. While peripheral blood mononuclear cells from exercising horses exhibit greater responsiveness to IL-2, this is not due to an increase in IL-2 receptor expression. LAK cell generation in vitro is augmented by those catecholamines and neuropeptides which are produced during exercise, suggesting a direct effect of these compounds on LAK cell generation at a step post IL-2 receptor binding.

References

Apr 1, 1992·Veterinary Immunology and Immunopathology·C E HormanskiD W Horohov
Sep 1, 1991·Endocrinology·J J McGloneR L Norman
Jan 1, 1991·Veterinary Research Communications·N V AndersonG A Kennedy
Oct 1, 1990·Proceedings of the Society for Experimental Biology and Medicine·J R Simpson, L Hoffman-Goetz
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Aug 1, 1994·Immunology Today·L Hoffman-Goetz, B K Pedersen
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Citations

Oct 31, 2002·Equine Veterinary Journal. Supplement·P T ColahanJ H Jones
May 27, 2011·Equine Veterinary Journal. Supplement·N R LiburtK H McKeever
Sep 15, 2012·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Douglas R AbdallaMárcia A Michelin
Mar 18, 2003·Equine Veterinary Journal·D W Horohov

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