Mechanism of fluid infusion during microneedle insertion and retraction

Journal of Controlled Release : Official Journal of the Controlled Release Society
Wijaya MartantoMark R Prausnitz

Abstract

Previous work has shown that infusion flow rates can be increased by an order of magnitude by partially retracting microneedles after insertion into the skin. This study sought to determine the mechanism by which retraction increases fluid infusion by piercing human cadaver skin with single microneedles, fixing the skin after retracting microneedles to different distances, and examining skin microstructure by histology. We found that microneedle insertion to 1080 microm from the skin surface resulted primarily in skin indentation and only 100-300 microm penetration into the skin. This caused significant compaction of the skin, which probably pressed out most water and thereby dramatically lowered the flow conductivity of skin beneath the needle tip. Retraction of the microneedle allowed the skin to recoil back toward its original position, which relieved the skin compaction and increased local flow conductivity. Altogether, these results suggest that microneedle insertion to penetrate into the skin followed by microneedle retraction to relieve skin compaction is an effective approach to infuse fluid into the skin in a minimally invasive manner.

References

Jan 1, 1992·Annals of Biomedical Engineering·P J Rousche, R A Normann
Nov 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Devin V McAllisterMark R Prausnitz
Mar 17, 2004·Advanced Drug Delivery Reviews·Mark R Prausnitz
May 20, 2004·The British Journal of Dermatology·F ChabriJ Birchall
Jun 24, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Michel CormierPete Daddona
Sep 21, 2004·Biomedical Microdevices·Ming Yang, Jeffrey D Zahn
Apr 6, 2005·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Raja K SivamaniHoward Maibach
Nov 26, 2005·Pharmaceutical Research·Wijaya MartantoMark R Prausnitz
Feb 18, 2006·The Journal of Investigative Dermatology·Ping M WangMark R Prausnitz

❮ Previous
Next ❯

Citations

Jun 29, 2007·Pharmaceutical Research·Chandra Sekhar Kolli, Ajay K Banga
Nov 4, 2008·Pharmaceutical Research·Jason JiangMark R Prausnitz
Sep 21, 2013·Biomaterials·Jacob W CoffeyMark A F Kendall
Feb 6, 2008·Proceedings of the National Academy of Sciences of the United States of America·Daniel P WermelingAudra L Stinchcomb
Apr 12, 2011·Computer Methods in Biomechanics and Biomedical Engineering·X Q KongC W Wu
Dec 14, 2012·Diabetes Technology & Therapeutics·Ahmed El-LaboudiDesmond Johnston
Mar 4, 2011·AAPS PharmSciTech·Haripriya Kalluri, Ajay K Banga
Sep 17, 2013·Drug Design, Development and Therapy·Xiaoyun HongWeien Yuan
Mar 30, 2012·International Journal of Nanomedicine·Sixing YangTuo Jin
Mar 20, 2015·Drug Delivery and Translational Research·James J NormanMark R Prausnitz
May 9, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sunaina IndermunViness Pillay
Jul 17, 2013·Advanced Drug Delivery Reviews·Eric Nuxoll
Jun 17, 2014·Biological & Pharmaceutical Bulletin·Maleenart PetchsangsaiTanasait Ngawhirunpat
Aug 20, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Xinyuan ChenMei X Wu
Nov 19, 2008·The Journal of Dermatological Treatment·Raja K SivamaniHoward I Maibach
Jul 7, 2011·Expert Review of Medical Devices·Martin J GarlandRyan F Donnelly
Apr 8, 2009·Expert Opinion on Drug Delivery·Ajay K Banga
Dec 23, 2006·Expert Opinion on Drug Delivery·Raja K SivamaniHoward I Maibach
Jan 16, 2013·Expert Opinion on Drug Delivery·Sachiko HirobeShinsaku Nakagawa
Mar 20, 2010·Drug Delivery·Ryan F DonnellyA David Woolfson
Sep 13, 2013·Journal of Pharmaceutical Sciences·Jaspreet Singh KochharLifeng Kang
Jul 28, 2012·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Yasmine A GomaaRyan F Donnelly
Feb 24, 2016·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Rishad R JivaniBhagyesh P Jhala
May 12, 2012·Advanced Drug Delivery Reviews·Yeu-Chun KimMark R Prausnitz
Dec 15, 2011·Advanced Drug Delivery Reviews·Shilpa SantAli Khademhosseini
Sep 28, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Suzanne M BalJoke A Bouwstra
Aug 25, 2010·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Yasmine A GomaaVictor M Meidan
Jul 24, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Suzanne M BalMartina C Meinke
Jul 14, 2010·International Journal of Pharmaceutics·Young-Wook NohCheong-Weon Cho
Jan 26, 2010·International Journal of Pharmaceutics·Wei-Ze LiYong Zhang
Jan 17, 2009·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·M M BadranA Fahr
Apr 9, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·F J VerbaanJ A Bouwstra
Jan 2, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·F J VerbaanJ A Bouwstra
Oct 13, 2012·The Journal of Pharmacy and Pharmacology·Yasmine A GomaaVictor M Meidan
May 24, 2007·IEEE Transactions on Bio-medical Engineering·Jung-Hwan ParkMark G Allen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Pharmaceutical Research
Wijaya MartantoMark R Prausnitz
Journal of Controlled Release : Official Journal of the Controlled Release Society
F J VerbaanJ A Bouwstra
Advanced Drug Delivery Reviews
Mark R Prausnitz
Proceedings of the National Academy of Sciences of the United States of America
D V McAllisterMark R Prausnitz
Journal of Controlled Release : Official Journal of the Controlled Release Society
Jung-Hwan ParkMark R Prausnitz
© 2022 Meta ULC. All rights reserved