Mechanism of growth inhibition of melanoma cells by 4-S-cysteaminylphenol and its analogues

Biochemical Pharmacology
S InoueK Fujita

Abstract

Our previous studies have shown that 4-S-cysteaminylphenol (4-S-CAP) causes a significant inhibition of in vivo melanoma growth and a marked depigmentation of black skin and hair follicles. These studies have suggested a role of tyrosinase in the manifestation of these in vivo effects. In this study 4-S-CAP and its analogues were examined for their effects on the growth of human melanoma cells in vitro. 4-S-CAP and 4-S-HomoCAP exhibited strong cytotoxicity with effects much greater than those of alpha-methyl-4-S-CAP and N,N-dimethyl-4-S-CAP. The cytotoxicity of the former two amines was completely prevented by semicarbazide, an inhibitor of plasma monoamine oxidase, while that of the latter two was not prevented by semicarbazide, catalase, and phenylthiourea, a tyrosinase inhibitor. In culture medium 4-S-CAP was rapidly converted by the action of monoamine oxidase present in fetal bovine serum to the aldehyde which was then metabolized to the alcohol and the carboxylic acid when cells were present. alpha-Methyl-4-S-CAP was found to exert higher cytotoxicity to cells with higher tyrosinase activity and melanin content. These results suggest that the in vitro cytotoxicity of 4-S-CAP and 4-S-HomoCAP is mediated through conversion ...Continue Reading

References

Oct 15, 1987·Biochemical Pharmacology·S InoueK Fujita
May 1, 1988·The Journal of Investigative Dermatology·T NakamuraT Kasuga
May 1, 1987·The Journal of Investigative Dermatology·I YamadaT Kasuga
May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·M E MorrisonG Cohen
Dec 1, 1971·Archives of Biochemistry and Biophysics·B K HartmanS Udenfriend
Sep 15, 1982·Biochemical Pharmacology·M KawaseM Okada
Dec 31, 1982·Biochemical and Biophysical Research Communications·H TjälveS Henningsson
Feb 1, 1980·The Journal of Investigative Dermatology·M M Wick

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Citations

Jun 1, 1994·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·T IwashinaL I Wiebe
Nov 11, 2010·Journal of Agricultural and Food Chemistry·Zhi-Cong LiQing-Xi Chen

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