Mechanism of Human Influenza Virus RNA Persistence and Virion Survival in Feces: Mucus Protects Virions From Acid and Digestive Juices

The Journal of Infectious Diseases
Ryohei HiroseYoshito Itoh

Abstract

Although viral RNA or infectious virions have been detected in the feces of individuals infected with human influenza A and B viruses (IAV/IBV), the mechanism of viral survival in the gastrointestinal tract remains unclear. We developed a model that attempts to recapitulate the conditions encountered by a swallowed virus. While IAV/IBV are vulnerable to simulated digestive juices (gastric acid and bile/pancreatic juice), highly viscous mucus protects viral RNA and virions, allowing the virus to retain its infectivity. Our results suggest that virions and RNA present in swallowed mucus are not inactivated or degraded by the gastrointestinal environment, allowing their detection in feces.

References

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Citations

Jul 25, 2018·Frontiers in Microbiology·Thomas LabadieIndia Leclercq
Oct 4, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ryohei HiroseTakaaki Nakaya
Feb 17, 2021·Nature Reviews. Gastroenterology & Hepatology·Meng GuoShu Zhu
Apr 27, 2021·Physics of Fluids·Jesse H SchreckSiddhartha Verma
May 14, 2021·Frontiers in Immunology·Sílvia LlorensTomás Segura

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