PMID: 7021590Aug 1, 1981Paper

Mechanism of hyperreninemia in the potassium-depleted rat

The Journal of Clinical Investigation
S L Linas

Abstract

Although dietary potassium deficiency (KD) results in an increase in plasma renin activity (PRA), the mechanism of this effect has not been elucidated. In the present study, isolated kidneys from normal rats or from rats made KD by diet were perfused at constant pressure (120 mm Hg) with a Krebs-Ringer-Bicarbonate medium containing albumin. KD led to an increase in PRA (3.6 vs. 1.1 ng angiotensin I ml per h, P less than 0.01), which was associated with a decrease in macula densa (MD) fluid delivery as estimated by urine flow (70 vs. 166 microliters/min per g, P less than 0.005), and an increase in renal vascular resistance (RVR) as perfusion flow rate was decreased from 34 to 24 ml/min per g, P less than 0.005. The increase in PRA was independent of the MD because PRA could not be suppressed when macula densa delivery was increased by perfusing KD kidneys with hypooncotic albumin. Moreover, when kidneys were made nonfiltering by perfusing with hyperconcotic albumin, PRA remained increased in KD kidneys (8.1 vs. 3.5 ng angiotensin I ml per h, P less than 0.01) despite the absence of MD delivery. Because the increase in PRA in both filtering and nonfiltering KD kidneys was associated with an increase in RVR, filtering and nonfilt...Continue Reading

References

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Citations

Mar 1, 1995·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·D W LaightJ F Waterfall
Jul 5, 2001·Proceedings of the National Academy of Sciences of the United States of America·I ArrighiP Meneton
Sep 6, 2000·Clinical and Experimental Hypertension : CHE·M B PamnaniZ Mo
Sep 1, 1992·Kidney International·S L LinasJ E Repine
May 1, 1982·Kidney International·S L Linas, D Dickmann
Sep 1, 1983·Kidney International·M S Paller, S L Linas
Jan 25, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Manasvi JaitlyVelvie A Pogue
Jan 1, 1989·Annals of the New York Academy of Sciences·D YoshikamiB M Olivera
Sep 1, 1982·Hypertension·M S Paller, S L Linas
May 12, 1998·The American Journal of Physiology·D Z LevineJ N Fryer
Apr 7, 2000·Journal of the American Society of Nephrology : JASN·Hassan N Ibrahim, Thomas H Hostetter
Aug 1, 1985·Kidney International·P E KlotmanW E Yarger

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