PMID: 698044Aug 1, 1978Paper

Mechanism of impaired glucose tolerance in patients with neoplasia

British Journal of Cancer
B JasaniG S Sokhi

Abstract

The disappearance rate (k) of i.v. glucose was measured in cachectic and non-cachectic cancer patients and tumour-free controls. The respective k values were found to be 1.06 +/- 0.27 (mean +/- s.d.), 1.64 +/- 0.34 and 1.63 +/- 0.23. Of the other parameters measured, only plasma albumin level was found to vary significantly amongst the 3 categories, the mean level being the lowest in cachectic cancer patients. The means of total plasma protein, fasting blood glucose and plasma liver enzyme concentrations were similar in the 3 groups. Glucagon, a potent insulin secretogogue, failed to augment the fasting insulin level in cachectic but did so in non-cachectic cancer patients. Taken together, the findings suggest that the reduced glucose tolerance in patients with neoplasia is due to impairment of insulin release exhibited predominantly by ill-nourished advanced cancer patients having a moderate to sever degree of hypoalbuminemia.

Citations

Mar 1, 1983·JPEN. Journal of Parenteral and Enteral Nutrition·J ShearerJ L Mullen
Mar 1, 1990·The British Journal of Surgery·R G Douglas, J H Shaw
Aug 1, 1992·Journal of the American College of Nutrition·J A Tayek
Mar 28, 2012·Journal of Cachexia, Sarcopenia and Muscle·Mary A Honors, Kimberly P Kinzig
Dec 17, 2014·Nutrition and Cancer·Patrizia MondelloVincenzo Pitini
Jan 31, 2018·Diabetes, Obesity & Metabolism·Anne Cathrine B Thuesen, Allan Vaag
May 5, 2018·BioMed Research International·Jean-Philippe ParvyJulia B Cordero
Nov 1, 1987·The British Journal of Surgery·G P CopelandL J Hipkin
Nov 19, 2020·International Journal of Molecular Sciences·Elisabeth WyartPaolo E Porporato
Apr 4, 2021·International Journal of Molecular Sciences·Steffen H RaunLykke Sylow
May 14, 2021·CA: a Cancer Journal for Clinicians·Daniel R SchmidtJason W Locasale
Jan 1, 1981·The International Journal of Biochemistry·J SinghM P Thompson
Nov 1, 1983·The American Journal of Medicine·R S RivlinP Sherlock
Feb 1, 1986·Seminars in Oncology Nursing·A M Lindsey
Jan 1, 1987·Critical Reviews in Oncology/hematology·J A NortonS D Morrison

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cachexia & Brown Fat

Cachexia is a condition associated with progressive weight loss due to severe illness. In cancer patients, it is proposed to occur as a result of tumor-induced energy wasting. Several proteins have been implicated in browning and depletion of white adipose tissue. Here is the latest research on cachexia and brown fat.

Cardiac Cachexia

Cardiac cachexia is a syndrome associated with the progressive loss of muscle and fat mass. It most commonly affects patients with heart failure and can significantly decrease the quality of life and survival in these patients. Here is the latest research on cardiac cachexia.