Abstract
The effect of penetration enhancers like tulsi (basil) oil, eucalyptus oil, clove oil, black cumin oil, oleic acid and Tween 80 on the percutaneous absorption of model lipophilic drug-carvedilol was investigated using excised rat abdominal skin. Transdermal flux, permeability coefficient and enhancement factor were calculated for each penetration enhancer. Black cumin oil (5% v/v) was selected on the basis of its highest enhancement in permeation and was evaluated further for its mode of action using DSC, FTIR and histological studies. The results indicated that the oil shows its action by extraction of lipids from stratum corneum as well as by loosening the hydrogen bonds between ceramides subsequently leading to fluidization of the lipid bilayer.
References
Jan 1, 1992·Journal of Pharmaceutical Sciences·K SugibayashiY Morimoto
Dec 1, 1990·Journal of Pharmaceutical Sciences·B J AungstM A Hussain
Jan 1, 1987·Journal of Pharmaceutical Sciences·G M GoldenR O Potts
Mar 1, 1986·The Journal of Investigative Dermatology·G M GoldenR O Potts
Apr 1, 1995·The Journal of Pharmacy and Pharmacology·C S Leopold, B C Lippold
Oct 12, 1994·Biochimica Et Biophysica Acta·C Y Goates, K Knutson
Mar 1, 1996·Pharmaceutical Research·S MitragotriR Langer
Apr 1, 1996·European Journal of Drug Metabolism and Pharmacokinetics·J Hadgraft
Jun 13, 1998·The Journal of Pharmacy and Pharmacology·R H Guy
Jul 30, 1999·International Journal of Pharmaceutics·J Hadgraft
Oct 21, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·B A van den BerghP W Wertz
May 2, 2000·Drug Development and Industrial Pharmacy·S C ShinC W Cho
May 29, 2000·Journal of Pharmaceutical Sciences·K Zhao, J Singh
Jul 13, 2002·Journal of Pharmaceutical Sciences·H K VaddiS Y Chan
Nov 1, 1964·The Journal of Investigative Dermatology·I H BLANK
Mar 17, 2004·Advanced Drug Delivery Reviews·Robert Langer
Citations
Jun 29, 2010·Natural Product Research·Saima AminMohd Ali
Jun 29, 2010·AAPS PharmSciTech·Diksha Kaushik, Bozena Michniak-Kohn
Oct 6, 2012·Therapeutic Delivery·Sevgi Güngör, Yildiz Ozsoy
Apr 5, 2011·Annual Review of Analytical Chemistry·Zachary D Schultz, Ira W Levin
Oct 30, 2015·Pharmaceutical Biology·Abdul AhadAsgar Ali
Apr 8, 2011·Drug Development and Industrial Pharmacy·Abdul AhadAsgar Ali
May 17, 2014·Expert Opinion on Drug Delivery·Abdul AhadMohd Mujeeb
Feb 26, 2016·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Désirée SchneiderGintautas Korinth
Dec 25, 2015·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Abdul AhadMohd Aqil
Mar 24, 2016·International Journal of Pharmaceutics·Mohd KamranAsgar Ali
Jan 6, 2015·The Journal of Pharmacy and Pharmacology·Anna Herman, Andrzej P Herman
Dec 4, 2010·Drug Development and Industrial Pharmacy·Gurkishan ChadhaR Jayachandra Babu
Aug 19, 2010·Pharmaceutical Development and Technology·Eszter CsizmaziaErzsébet Csányi
Mar 4, 2017·Biointerphases·Vytis ČižinauskasVitalis Briedis
Apr 13, 2017·Pharmaceutical Biology·Qiudong JiangJinao Duan
Dec 28, 2019·Drug Development and Industrial Pharmacy·Jie DongJun Chen
Jul 19, 2021·Drug Delivery and Translational Research·Katayoun Morteza-SemnaniAli Nokhodchi