Mechanism of increased renal gene expression during metabolic acidosis

American Journal of Physiology. Renal Physiology
Norman P Curthoys, Gerhard Gstraunthaler

Abstract

Increased renal catabolism of plasma glutamine during metabolic acidosis generates two ammonium ions that are predominantly excreted in the urine. They function as expendable cations that facilitate the excretion of acids. Further catabolism of alpha-ketoglutarate yields two bicarbonate ions that are transported into the venous blood to partially compensate for the acidosis. In rat kidney, this adaptation is sustained, in part, by the induction of multiple enzymes and various transport systems. The pH-responsive increases in glutaminase (GA) and phosphoenolpyruvate carboxykinase (PEPCK) mRNAs are reproduced in LLC-PK(1)-fructose 1,6-bisphosphatase (FBPase) cells. The increase in GA activity results from stabilization of the GA mRNA. The 3'-untranslated region of the GA mRNA contains a direct repeat of an eight-base AU sequence that functions as a pH-response element. This sequence binds zeta-crystallin/NADPH:quinone reductase with high affinity and specificity. Increased binding of this protein during acidosis may initiate the pH-responsive stabilization of the GA mRNA. In contrast, induction of PEPCK occurs at the transcriptional level. In LLC-PK(1)-FBPase(+) kidney cells, a decrease in intracellular pH leads to activation of ...Continue Reading

References

Sep 1, 1978·The American Journal of Physiology·H B BurchO H Lowry
Mar 1, 1992·The American Journal of Physiology·S KaiserNorman P Curthoys
Jul 1, 1992·The American Journal of Physiology·Gerhard GstraunthalerW Pfaller
Feb 25, 1991·Archives of Biochemistry and Biophysics·D GarlandJ S Zigler
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S HorieR J Alpern
Dec 1, 1990·The American Journal of Physiology·P A Wright, Mark A Knepper
Dec 1, 1990·The American Journal of Physiology·M Sastrasinh, S Sastrasinh
Jul 1, 1990·The American Journal of Physiology·P A Wright, Mark A Knepper
Jan 1, 1990·The American Journal of Physiology·A SahaiR L Tannen
Dec 1, 1989·The American Journal of Physiology·S Sastrasinh, M Sastrasinh
Jan 1, 1985·The American Journal of Physiology·Gerhard GstraunthalerP Kotanko
Feb 1, 1987·The American Journal of Physiology·Gerhard Gstraunthaler, J S Handler
Aug 1, 1984·Kidney International·W G Guder, B D Ross
Mar 1, 1984·The Journal of Clinical Investigation·D W Good, M B Burg
Mar 1, 1983·The American Journal of Physiology·D P Simpson
May 7, 1982·Biochimica Et Biophysica Acta·Z Kovacević, K Bajin
Sep 1, 1981·Kidney International·I M SajoM L Halperin
Mar 1, 1980·The American Journal of Physiology·R P HugheyNorman P Curthoys
May 15, 1980·The Biochemical Journal·H SchröckL Goldstein
Sep 15, 1980·The Biochemical Journal·M Lowry, B D Ross
Sep 1, 1995·The American Journal of Physiology·D PorterNorman P Curthoys
Feb 1, 1995·The American Journal of Physiology·T HolcombGerhard Gstraunthaler
Mar 1, 1994·Trends in Biochemical Sciences·M W Hentze
Jan 1, 1995·Annual Review of Nutrition·Norman P Curthoys, M Watford
Mar 1, 1996·The American Journal of Physiology·X Mu, Tomas Welbourne
Jul 1, 1996·The American Journal of Physiology·W R HansenNorman P Curthoys
Aug 1, 1996·The American Journal of Physiology·T HolcombNorman P Curthoys
Jan 1, 1997·Annual Review of Biochemistry·R W Hanson, Lea Reshef
Jan 1, 1997·Contributions to Nephrology·K DrewnowskaA C Schoolwerth
May 4, 1999·The International Journal of Biochemistry & Cell Biology·R McCauleyJ C Hall
Feb 9, 2000·American Journal of Physiology. Renal Physiology·Gerhard GstraunthalerNorman P Curthoys
Jun 3, 2000·American Journal of Physiology. Renal Physiology·O F Laterza, Norman P Curthoys
Mar 27, 2001·Biochimica Et Biophysica Acta·L TaylorNorman P Curthoys

Citations

Sep 10, 2002·American Journal of Physiology. Renal Physiology·Elisabeth FeifelGerhard Gstraunthaler
Feb 13, 2003·Cell Biochemistry and Function·Philip NewsholmeRui Curi
May 27, 2005·Critical Reviews in Biochemistry and Molecular Biology·Kaushik ChakravartyRichard W Hanson
Oct 13, 2005·American Journal of Physiology. Renal Physiology·Jill M SchroederNorman P Curthoys
May 16, 2006·American Journal of Nephrology·Hassane AmlalManoocher Soleimani
Jul 27, 2006·Physiological Genomics·Lydie ChevalAlain Doucet
Dec 7, 2007·Physiological Genomics·Marta NowikCarsten A Wagner
Jan 23, 2008·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Xuming SunSnezana Petrovic
Mar 12, 2009·Pflügers Archiv : European journal of physiology·Carsten A WagnerNilufar Mohebbi
May 22, 2009·American Journal of Physiology. Renal Physiology·Stephanie M Busque, Carsten A Wagner
Dec 17, 2010·Pharmaceutical Research·Arong GaowaKen-ichi Inui
Jul 29, 2011·American Journal of Physiology. Renal Physiology·Shaikh Abu HossainHassane Amlal
May 25, 2012·American Journal of Physiology. Renal Physiology·Sara M MolinasRaúl A Marinelli
Jun 28, 2013·American Journal of Physiology. Renal Physiology·Kevin L SchauerNorman P Curthoys
Sep 12, 2019·Proceedings of the National Academy of Sciences of the United States of America·Parker C WilsonBenjamin D Humphreys
Sep 30, 2019·Cellular and Molecular Life Sciences : CMLS·Matteo LulliNicola Schiavone
Jun 5, 2002·Physiological Genomics·L David PorterNorman P Curthoys
Sep 25, 2003·American Journal of Physiology. Renal Physiology·Tomas WelbourneItzhak Nissim
Jun 24, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Inmaculada López-FloresJuan B Barroso
Aug 10, 2006·American Journal of Physiology. Renal Physiology·Norman P CurthoysMark A Knepper
May 9, 2012·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Eun Young KimSoo Wan Kim
Sep 1, 2004·Biochemistry and Molecular Biology Education : a Bimonthly Publication of the International Union of Biochemistry and Molecular Biology·Lynn Taylor, Norman P Curthoys
Mar 30, 2013·Journal of the American Society of Nephrology : JASN·Abdul SoofiGregory R Dressler
May 15, 2015·American Journal of Physiology. Renal Physiology·Xuming SunSnezana Petrovic
Jan 18, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Taku HirataShigehisa Hirose
Oct 10, 2002·American Journal of Physiology. Renal Physiology·Anne M KarinchWiley W Souba
Aug 19, 2007·Current Opinion in Nephrology and Hypertension·Carsten A Wagner
Dec 17, 2008·Metabolic Brain Disease·Giacomo GaribottoMaria Teresa Gandolfo
Sep 28, 2006·American Journal of Physiology. Renal Physiology·Caroline MoretCarsten A Wagner
Apr 10, 2003·American Journal of Physiology. Renal Physiology·Jill M SchroederNorman P Curthoys
Aug 15, 2008·American Journal of Physiology. Renal Physiology·Gamika A PrathapasingheKarmin O
Mar 16, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Franziska StellmerChris Mühlhausen
Nov 7, 2013·Pflügers Archiv : European journal of physiology·Stefan Bröer
Nov 17, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Eva Feigerlová, Shyue-Fang Battaglia-Hsu
Oct 30, 2018·Journal of Cellular Physiology·Myat Theingi SweAnusorn Lungkaphin
Dec 13, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Dalila Azzout-MarnicheDaniel Tomé
May 3, 2014·Clinical Journal of the American Society of Nephrology : CJASN·Melanie P Hoenig, Mark L Zeidel
Jul 29, 2009·The Journal of Biological Chemistry·Jianqi YangRichard W Hanson
Jul 1, 2016·Channels·Isabel Rubio-Aliaga, Carsten A Wagner
Feb 1, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Helen ChristouStella Kourembanas
Jun 29, 2007·American Journal of Physiology. Renal Physiology·Manfred AndratschGerhard Gstraunthaler
Feb 3, 2005·American Journal of Physiology. Renal Physiology·Robert OliverTomas Welbourne
Apr 22, 2015·The Journal of Clinical Investigation·P Richard GrimmPaul A Welling
Nov 9, 2012·American Journal of Physiology. Renal Physiology·Dana M FreundNorman P Curthoys
May 9, 2014·American Journal of Physiology. Renal Physiology·Norman P Curthoys, Gerhard Gstraunthaler

Related Concepts

Metabolic Acidosis
Metazoa
Phosphate-Activated Glutaminase
Fructose-1,6-Bisphosphatase
Kidney
GTP-Dependent Phosphoenolpyruvate Carboxykinase
Transcription, Genetic
Gene Expression Regulation, Enzymologic

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