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Mechanism of inhibition of eukaryotic protein synthesis by trichothecene fungal toxins

Proceedings of the National Academy of Sciences of the United States of America

Jan 1, 1974

E CundliffeJ E Davies

PMID: 4521056

Abstract

The 12,13-epoxytrichothecenes, a group of sesquiterpenoid fungal antibiotics, inhibit protein synthesis in eukaryotic cells but do not share a common mode of action. Trichodermin stabilizes polyribosomes, prevents their disaggregation by puromycin, and also prevents the release of nasce...read more

Mentioned in this Paper

Anisomycin
Polyribosomes
Set of Polysomal Ribosomes
Antibiotic throat preparations
Structure-Activity Relationship
T-2 Toxin
Peptide Chain Termination, Translational
Antifungal Antibiotics, Topical
Pyrrolidines
Transcription Initiation
43
1
Paper Details
References
  • References10
  • Citations100
1
  • References10
  • Citations100
12345...

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Mechanism of inhibition of eukaryotic protein synthesis by trichothecene fungal toxins

Proceedings of the National Academy of Sciences of the United States of America

Jan 1, 1974

E CundliffeJ E Davies

PMID: 4521056

DOI:

Abstract

The 12,13-epoxytrichothecenes, a group of sesquiterpenoid fungal antibiotics, inhibit protein synthesis in eukaryotic cells but do not share a common mode of action. Trichodermin stabilizes polyribosomes, prevents their disaggregation by puromycin, and also prevents the release of nasce...read more

Mentioned in this Paper

Anisomycin
Polyribosomes
Set of Polysomal Ribosomes
Antibiotic throat preparations
Structure-Activity Relationship
T-2 Toxin
Peptide Chain Termination, Translational
Antifungal Antibiotics, Topical
Pyrrolidines
Transcription Initiation
43
1

Feeds With Similar Papers

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

Toxicology and Applied Pharmacology

Inhibitory effect of Fusarium T2-toxin on lymphoid DNA and protein synthesis(opens in new tab)

Toxicology and Applied PharmacologySeptember 15, 1983
Y Rosenstein, C Lafarge-Frayssinet
Paper Details
References
  • References10
  • Citations100
1
  • References10
  • Citations100
12345...

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