Mechanism of interrupted saccades in patients with late-onset Tay-Sachs disease.

Progress in Brain Research
Lance M OpticanR John Leigh

Abstract

In late-onset Tay-Sachs disease (LOTS), saccades are interrupted by one or more transient decelerations. Some saccades reaccelerate and continue on before eye velocity reaches zero, even in darkness. Intervals between successive decelerations are not regularly spaced. Peak decelerations of horizontal and vertical components of oblique saccades in LOTS is more synchronous than those in control subjects. We hypothesize that these decelerations are caused by dysregulation of the fastigial nuclei (FN) of the cerebellum, which fire brain stem inhibitory burst neurons (IBNs).

References

Oct 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·J ChernC M Croce
Apr 19, 2002·Annals of the New York Academy of Sciences·Lance M Optican, Christian Quaia
Dec 10, 2003·Annals of the New York Academy of Sciences·Edward L Keller, Marcus Missal

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Citations

Feb 9, 2017·The Journal of Physiology·Francesca RosiniAlessandra Rufa
Nov 25, 2017·Frontiers in Neurology·Elena Pretegiani, Lance M Optican
Apr 29, 2015·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·E PretegianiA Rufa
Nov 30, 2018·Movement Disorders : Official Journal of the Movement Disorder Society·Lisette H KoensTom J de Koning
Jan 1, 2017·Expert Review of Ophthalmology·Sushant Puri, Aasef G Shaikh
Apr 12, 2021·Journal of Computational Neuroscience·Janet C RuckerLance M Optican

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