PMID: 2115090Aug 1, 1990Paper

Mechanism of killing by virus-induced cytotoxic T lymphocytes elicited in vivo

Journal of Virology
R M WelshP L Dundon

Abstract

The mechanism of lysis by in vivo-induced cytotoxic T lymphocytes (CTL) was examined with virus-specific CTL from mice infected with lymphocytic choriomeningitis virus (LCMV). LCMV-induced T cells were shown to have greater than 10 times the serine esterase activity of T cells from normal mice, and high levels of serine esterase were located in the LCMV-induced CD8+ cell population. Serine esterase was also induced in purified T-cell preparations isolated from mice infected with other viruses (mouse hepatitis, Pichinde, and vaccinia). In contrast, the interferon inducer poly(I.C) only marginally enhanced serine esterase in T cells. Serine esterase activity was released from the LCMV-induced T cells upon incubation with syngeneic but not allogeneic LCMV-infected target cells. Both cytotoxicity and the release of serine esterase were calcium dependent. Serine esterase released from disrupted LCMV-induced T cells was in the form of the fast-sedimenting particles, suggesting its inclusion in granules. Competitive substrates for serine esterase blocked killing by LCMV-specific CTL, but serine esterase-containing granules isolated from LCMV-induced CTL, in contrast to granules isolated from a rat natural killer cell tumor line, did n...Continue Reading

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Citations

Jan 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Luana O AtherlyLeslie J Berg
Nov 8, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Firzan NainuYoshinobu Nakanishi
May 5, 1997·The Journal of Experimental Medicine·C C Zarozinski, R M Welsh
Aug 30, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Joshua ChoiS M Mansour Haeryfar
Jun 1, 1991·Current Opinion in Immunology·G Berke

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