Mechanism of kinin release during experimental acute pancreatitis in rats: evidence for pro- as well as anti-inflammatory roles of oedema formation

British Journal of Pharmacology
T GriesbacherBernhard A Peskar

Abstract

1 Kinin B(2) receptor antagonists or tissue kallikrein (t-KK) inhibitors prevent oedema formation and associated sequelae in caerulein-induced pancreatitis in the rat. We have now further investigated the mechanism of kinin generation in the pancreas. 2 Kinins were elevated in the pancreatic tissue already before oedema formation became manifest. Peak values (421+/-59 pmol g(-1) dry wt) were reached at 45 min and remained elevated for at least 2 h; a second increase was observed at 24 h. Pretreatment with the B(2) receptor antagonist icatibant abolished kinin formation, while post-treatment was ineffective. 3 Total kininogen levels were very low in the pancreas of controls, but increased 75-fold during acute pancreatitis. This increase was absent in rats that were pretreated with icatibant. 4 During pancreatitis, t-KK-like and plasma kallikrein (p-KK)-like activity in the pancreas, as well as trypsinogen activation peptide (TAP) increased significantly. Icatibant pretreatment further augmented t-KK about 100-fold, while p-KK was significantly attenuated; TAP levels remained unaffected. 5 Endogenous protease inhibitors (alpha(1)-antitrypsin, alpha(2)-macroglobulin) were low in normal tissues, but increased 45- and four-fold, res...Continue Reading

References

Mar 11, 1977·Virchows Archiv. A, Pathological Anatomy and Histology·M Lampel, H F Kern
Jan 1, 1979·Advances in Experimental Medicine and Biology·E AmundsenG Claeson
Mar 1, 1991·British Journal of Pharmacology·K WirthJ Knolle
Oct 1, 1992·British Journal of Pharmacology·T Griesbacher, F Lembeck
Feb 1, 1991·British Journal of Pharmacology·F LembeckJ Knolle
Mar 17, 1988·Biochimica Et Biophysica Acta·J ChaoL Chao
Jan 1, 1988·Methods in Enzymology·L M Greenbaum, H Okamoto
Jan 1, 1988·Annual Review of Immunology·D Proud, A P Kaplan
Jan 15, 1987·The New England Journal of Medicine·M L Steer, J Meldolesi
Jan 1, 1986·Advances in Experimental Medicine and Biology·Y Uchida, M Katori
Aug 1, 1970·The Journal of Experimental Medicine·P C Harpel
Jun 12, 1974·Naunyn-Schmiedeberg's Archives of Pharmacology·H Juan, F Lembeck
Jan 1, 1983·General Pharmacology·F MarceauJ P Giroud
Jan 1, 1982·European Journal of Clinical Pharmacology·W H HörlA Heidland
Jan 1, 1982·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M Bendayan, T B Orstavik
Jan 1, 1995·Life Sciences·Y HagiwaraS Oh-ishi
May 1, 1995·Naunyn-Schmiedeberg's Archives of Pharmacology·J DamasJ C Pinto
Mar 1, 1993·Trends in Neurosciences·A Dray, M Perkins
Aug 1, 1994·The British Journal of Surgery·A K BanerjeeA N Kingsnorth
Aug 1, 1993·Canadian Journal of Physiology and Pharmacology·D RegoliN E Rhaleb
Jan 1, 1993·Agents and Actions. Supplements·K M HargreavesJ Q Swift
Feb 1, 1993·British Journal of Pharmacology·T GriesbacherF Lembeck
Sep 2, 1999·The Surgical Clinics of North America·S Karne, F S Gorelick
Jun 13, 2000·Advances in Experimental Medicine and Biology·M M LerchB Krüger
Sep 22, 2000·Molecular Pharmacology·C HecquetE G Erdös
Dec 1, 2000·Scandinavian Journal of Gastroenterology·I A ElandB H Stricker
Jan 1, 1991·HPB Surgery : a World Journal of Hepatic, Pancreatic and Biliary Surgery·W Uhl, H G Beger

❮ Previous
Next ❯

Citations

Jan 19, 2011·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·M BhandariG T P Saccone
Mar 23, 2010·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Anna Andrzejewska, Jan W Dlugosz
Apr 17, 2007·Life Sciences·Hiroyasu IshikuraAtsufumi Kawabata
Oct 19, 2004·Neuroscience Research·Paula J W Smith, Daniel S McQueen
Dec 6, 2005·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Thomas GriesbacherDiana Groisman
Feb 10, 2018·The Journal of Physiology·Oleksiy GryshchenkoOle H Petersen
Oct 7, 2004·Rapid Communications in Mass Spectrometry : RCM·John M KoomenRyuji Kobayashi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.