PMID: 11332030May 3, 2001Paper

Mechanism of lipid peroxidation photosensitized by tiaprofenic acid: product studies using linoleic acid and 1,4-cyclohexadienes as model substrates

Photochemistry and Photobiology
A SamadiI M Morera

Abstract

A careful study of the linoleic acid hydroperoxide (LOOH) profile obtained upon peroxidation of linoleic acid (LA) photosensitized by tiaprofenic acid (TPA) and analogous ketones has been undertaken to distinguish between type-I and type-II photoperoxidation mechanisms. 1,4-Cyclohexadiene and 1,2-dimethylcyclohexa-2,5-dienecarboxylic acid (CHDCA) have also been used as models for LA since they also have double allylic systems. Coirradiation of LA with TPA and decarboxytiaprofenic acid (DTPA) in acetonitrile and micellar media produced significant amounts of conjugated dienic LOOH. The cis,trans to trans,trans ratio depended on the irradiation time; thus, this parameter is an ambiguous tool for mechanistic assignment. An interesting finding was the decrease of the LOOH level after long irradiation times in mixtures photooxidized by DTPA, which is attributed to quenching of the DTPA triplet by the generated dienic LOOH. High-performance liquid chromatography analyses confirmed that the main pathway operating in photodynamic lipid peroxidation sensitized by (D)TPA is a type-I mechanism. However, product studies using CHDCA have clearly shown that a type-II mechanism is also operating and might contribute to the overall photooxidat...Continue Reading

References

Apr 1, 1990·Photochemistry and Photobiology·A W Girotti
Jan 1, 1984·Methods in Enzymology·N A Porter
Jan 1, 1984·Methods in Enzymology·W A Pryor, L Castle
Oct 1, 1995·Journal of the American Academy of Dermatology·J W GouldC A Elmets
May 1, 1993·Journal of Photochemistry and Photobiology. B, Biology·A FigueiredoF Teixeira
Mar 1, 1993·Photochemistry and Photobiology·J V CastellP Tarrega
Jun 26, 1998·Journal of Photochemistry and Photobiology. B, Biology·F Boscá, M A Miranda
Oct 18, 2000·Free Radical Biology & Medicine·A Sevanian, F Ursini
Feb 24, 2001·Journal of Photochemistry and Photobiology. B, Biology·F BoscáA Samadi

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Citations

Jul 28, 2011·Chemistry : a European Journal·Inmaculada AndreuMiguel A Miranda

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