Mechanism of liver tyrosine aminotransferase increase in ethanol-treated mice and its effect on serum tyrosine level

Journal of Nutritional Science and Vitaminology
Shigeko Fujimoto SakataNanaya Tamaki

Abstract

Liver tyrosine aminotransferase (TAT) activity is known to increase with ethanol treatment; however, the mechanism of this increase is unclear. Upon investigation we found that TAT activity and mRNA levels started to increase 2 h after ethanol administration and continued to increase until 6 h after ethanol administration. The increase in ethanol-induced TAT activity could not be explained by calorie loading after fasting, since ethanol loading increased TAT expression, while glucose loading decreased TAT expression. In addition, liver TAT activity was not related to serum tyrosine levels. TAT activity increased when an adenosine A2 agonist, 5'-N-ethylcarboxamide adenosine, was given. Since TAT activity is increased by cAMP, and ethanol increases cAMP production via an adenosine receptor-dependent mechanism, this increase in ethanol-induced TAT activity may occur via an adenosine receptor-dependent mechanism.

References

Oct 1, 1992·Archives of Biochemistry and Biophysics·J L MessinaR S Weinstock
Sep 30, 1988·Biochemical and Biophysical Research Communications·T M DonohueR K Zetterman
Jan 1, 1985·The International Journal of Biochemistry·L C WardR Daly
Dec 14, 1970·Journal of Molecular Biology·E B ThompsonG M Tomkins
Feb 1, 1981·Digestive Diseases and Sciences·J M HendersonD Rudman
May 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·C LondosJ Wolff
Dec 7, 1984·Journal of Chromatography·B A BidlingmeyerT L Tarvin
Sep 1, 1995·Trends in Pharmacological Sciences·V RamkumarS B Maggirwar
Apr 1, 1993·European Journal of Clinical Chemistry and Clinical Biochemistry : Journal of the Forum of European Clinical Chemistry Societies·D J ByrdJ Brodehl
Dec 1, 1995·General Pharmacology·M SharifzadehM Samini
May 20, 1998·Proceedings of the National Academy of Sciences of the United States of America·H SassiT Grange
Jun 11, 1998·Alcoholism, Clinical and Experimental Research·H SuzukiM Suzuki
Jul 19, 2005·Journal of Nutritional Science and Vitaminology·Shigeko Fujimoto SakataNanaya Tamaki
Apr 1, 1989·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·M FreyszM Wilkening

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