Mechanism of mechanical inhibition of smooth muscle by ouabain.

British Journal of Pharmacology
D Bose

Abstract

1 Ouabain (10 mug/ml) caused an initial increase followed by a decrease in tension in guinea-pig taenia coli bathed in normal sodium and potassium containing medium. 2 The excitatory effect of ouabain was prevented by the elevation of extracellular potassium while the inhibitory effect was abolished in the absence of sodium in the bathing medium. 3 In the presence of sodium, the inhibitory effect of ouabain disappeared when the drug was washed out, but in the presence of lithium (which is not extruded by the Na-K pump) the inhibition was not abolished. 4 The inhibitory effect of ouabain was accompanied by an increase in tissue Na and a decrease in tissue K concentration. The increase in intracellular [45Ca] which occurred when extracellular [k] was varied, was also reduced by ouabain. 5 It is concluded that a high intracellular level of sodium inhibits contractions in visceral smooth muscle probably by a mechanism involving decreased Ca influx.

References

Mar 15, 1973·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·H ReuterG Haeusler
Aug 1, 1974·Canadian Journal of Physiology and Pharmacology·D Bose
Sep 1, 1961·The Journal of Physiology·J AXELSSON

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Citations

Jun 4, 1982·European Journal of Pharmacology·H OzakiN Urakawa
Oct 15, 1982·European Journal of Pharmacology·T KishimotoY Ishida
Oct 11, 1988·European Journal of Pharmacology·J YamaharaH Fujimura
Jan 1, 1989·General Pharmacology·M NishimuraO Yagasaki
Jan 1, 1987·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·H OzakiN Urakawa
Jan 1, 1991·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·T NasuH Shibata
Jan 1, 1977·The American Journal of Physiology·T S Ma, D Bose

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