Mechanism of penicillin killing in the absence of bacterial lysis.

Antimicrobial Agents and Chemotherapy
T D McDowell, K E Reed

Abstract

Exposure of group A streptococci (a nonlytic-death phenotype) to benzylpenicillin (penicillin G) produced a dose-dependent, rapid, and extensive hydrolysis of total cellular RNA, with the subsequent loss of hydrolysis products from the cell. This loss of RNA correlated well with loss of viability and was not accompanied by solubilization of the cell wall or comparable losses of either protein or DNA. Simultaneous treatment with penicillin G and either chloramphenicol or rifampin resulted in reduced levels of killing and the complete inhibition of RNA loss. These findings define a new mechanism of penicillin G-induced killing in the absence of cell wall disruption and suggest a basis for drug-induced antagonism of penicillin G-mediated nonlytic death.

References

Dec 1, 1979·Journal of Bacteriology·K Kitano, A Tomasz
May 1, 1977·Antimicrobial Agents and Chemotherapy·D Horne, A Tomasz
Apr 1, 1975·Infection and Immunity·B TerleckyjG D Shockman
Jul 1, 1975·Proceedings of the Society for Experimental Biology and Medicine·V LorianD W Watson
Mar 1, 1976·Infection and Immunity·S J MattinglyG D Shockman
Aug 1, 1985·The Journal of Infectious Diseases·H H Liu, A Tomasz
Jul 1, 1970·Journal of Bacteriology·M L Higgins, G D Shockman
Mar 1, 1971·Journal of Bacteriology·G S RothL Daneo-Moore
Apr 1, 1980·Antimicrobial Agents and Chemotherapy·M MychajlonkaG D Shockman
Jul 1, 1982·Antimicrobial Agents and Chemotherapy·L Gutmann, A Tomasz
Feb 1, 1980·Infection and Immunity·I van de Rijn, R E Kessler
Jul 1, 1957·Journal of Bacteriology·L S PRESTIDGE, A B PARDEE

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