Mechanism of plasminogen activator and factor VIII increase after vasoactive drugs.

British Journal of Haematology
P M MannucciB Robertson

Abstract

Adrenaline, nicotinic acid (NA), vasopressin (LVP) and other drugs affecting vascular motility are known to increase plasminogen activator (PA) and factor-VIII plasma levels in man. To evaluate the hypothesis that NA, LVP and adrenaline release PA from the endothelial cells of the vessel wall through their common effect on vascular motility, PA has been characterized by means of a histochemical technique on vein biopsies obtained from human volunteers after infusion of the compounds. Furthermore, the effect of single and repeated administration has been compared in order to investigate whether the pattern of PA and factor-VIII variations in plasma is similar with the three drugs. There was no major difference in the PA content of the veins following the marked and sustained increase of the corresponding plasma activities. A simple explanation is that the intensity and duration of the stimulus may not be sufficient to deplete the large stores of the vessel walls. The magnitude, time course and duration of the plasmatic response after single and repeated infusions was on the whole different and peculiar for each drug. A derivative of LVP which is free of vasoactive actions was more effective than LVP in inducing the responses, wh...Continue Reading

References

Dec 22, 1973·Lancet·A M GaderJ D Cash
Jul 15, 1967·Lancet·M PandolfiS Isacson
Apr 13, 1968·Lancet·I S MenonD J Newell
Feb 8, 1969·Lancet·G I Ingram, R V Jones
Nov 1, 1973·The Journal of Clinical Investigation·L W HoyerJ R Hoyer
Jun 1, 1970·Scandinavian Journal of Clinical and Laboratory Investigation·U HednerC D Jacobsen
Feb 1, 1971·British Journal of Haematology·P M MannucciG Gagnatelli
Apr 1, 1972·Acta Endocrinologica·K E AnderssonJ L Mulder
Apr 1, 1970·British Journal of Haematology·J D CashA G Allan
Mar 22, 1973·The New England Journal of Medicine·L Holmberg, I M Nilsson
Aug 18, 1973·British Medical Journal·C R EdwardsG M Besser
Jan 1, 1974·Scandinavian Journal of Haematology·L HolmbergI M Nilsson
May 1, 1973·The British Journal of Radiology·J A Archer-HallP E François
Jun 1, 1971·Acta Medica Scandinavica·U Hedner, M Nilsson
Jan 1, 1965·Advances in Clinical Chemistry·G I Ingram
Jan 1, 1970·Scandinavian Journal of Haematology·S Isacson
Jan 1, 1970·Scandinavian Journal of Haematology·S Isacson, I M Nilsson
Dec 22, 1970·Biochimica Et Biophysica Acta·J A van Mourik, I A Mochtar
Mar 1, 1967·Journal of Clinical Pathology·J D Cash, E Leask
Nov 1, 1968·Journal of Clinical Pathology·R ChakrabartiG R Fearnley
Nov 1, 1968·Biochemistry·E M Barrow, J B Graham
Sep 1, 1969·The American Journal of Physiology·W J Dodds
May 1, 1967·British Journal of Haematology·J D Cash, A G Allan
Feb 1, 1958·American Journal of Clinical Pathology·K N VON KAULLA, R L SCHULTZ
Aug 1, 1958·Proceedings of the Society for Experimental Biology and Medicine·M WEINERJ M STEELE
Jun 1, 1959·Circulation·M WEINERJ M STEELE
Jul 1, 1959·The Journal of Pathology and Bacteriology·A S TODD
Feb 1, 1960·The Journal of Clinical Endocrinology and Metabolism·E M GOLDS COOK
Mar 15, 1962·Experientia·K BULUK, M FURMAN
Oct 1, 1961·The American Journal of Medicine·E GENTONK VON KAULLA
Jan 1, 1962·Scandinavian Journal of Clinical and Laboratory Investigation·M PARASKEVASG MARTINSSON
Jul 5, 2007·Journal of Lipid Research·Barbara P AtshavesFriedhelm Schroeder

❮ Previous
Next ❯

Citations

Sep 1, 1992·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·N Knoers, L A Monnens
Oct 1, 1994·Annals of Hematology·S Lethagen
Jan 8, 1999·International Journal of Clinical & Laboratory Research·P M Mannucci
Mar 2, 1993·European Journal of Pharmacology·H VilhardtC J Aurell
Apr 29, 1993·Regulatory Peptides·J L David
Aug 1, 1987·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·A O AbubakerT W Braun
Jul 1, 1989·Molecular and Cellular Endocrinology·J Schwartz
Mar 15, 1994·European Journal of Pharmacology·A HirasawaG Tsujimoto
Sep 1, 1993·Baillière's Clinical Haematology·J D Pearson
Jan 5, 2000·Breast Cancer Research and Treatment·D F AlonsoD E Gomez
Jan 22, 2005·Seminars in Hematology·Francesco Rodeghiero, Giancarlo Castaman
Jan 6, 1983·The New England Journal of Medicine·P M MannucciT S Zimmerman
Jul 23, 1998·The New England Journal of Medicine·P M Mannucci
Aug 13, 2004·The New England Journal of Medicine·Pier Mannuccio Mannucci
Jun 1, 2007·The New England Journal of Medicine·Pier Mannuccio Mannucci, Marcel Levi
Mar 5, 2003·Journal of Neurotrauma·Yumiko AbeTomoatsu Kimura
Nov 11, 2003·Journal of Pediatric Hematology/oncology·Shoshana Revel-VilkVictor S Blanchette
Mar 1, 1979·British Journal of Haematology·C V ProwseJ D Cash
Jul 1, 1996·Haemophilia : the Official Journal of the World Federation of Hemophilia·G I Ingram, P M Mannucci
Jan 1, 1978·Acta paediatrica Scandinavica·P Henriksson, L Holmberg
Nov 16, 1985·British Medical Journal·A K BurroughsN McIntyre
Sep 1, 1983·Journal of Clinical Pathology·H LjungnérB Astedt
Feb 1, 1987·Journal of Neurology, Neurosurgery, and Psychiatry·W S AlmaaniM Z Karmi
Jun 1, 1976·The Journal of Clinical Investigation·F R RicklesD J Ahr
Jan 1, 1987·The Journal of Clinical Investigation·J A RibesD D Wagner
Jul 6, 2000·The Journal of Clinical Investigation·J E KaufmannU M Vischer
Mar 26, 2009·Blood·Simon F De MeyerKaren Vanhoorelbeke
May 13, 2011·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Anthony W AustinRoland von Känel
Jun 23, 1999·Seminars in Thoracic and Cardiovascular Surgery·G J DespotisL T Goodnough
Jul 1, 1979·La Ricerca in Clinica E in Laboratorio·P M Mannucci

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.