Mechanism of prostaglandin E2-, F2alpha- and latanoprost acid-induced relaxation of submental veins

European Journal of Pharmacology
M Astin, J Stjernschantz

Abstract

The mechanism of prostaglandin E2-, prostaglandin F2alpha- and latanoprost acid (13,14-dihydro-17-phenyl-18,19,20-trinor-prostaglandin F2alpha)-induced relaxation of the rabbit submental vein was studied. Prostaglandin E2 caused maximum relaxation of endothelin-1 precontracted vessels (EC50: 1.8 x 10(-8) M). Much of the relaxation could be abolished by denuding the endothelium with the nitric oxide synthase inhibitor, L-NAME (N(G)-Nitro-L-arginine methylester). CGRP-(8-37) (calcitonin gene-related peptide fragment (8-37)), a calcitonin gene-related peptide receptor antagonist, exhibited a partial blocking effect, whereas the tachykinin NK1 receptor blocker, GR 82334 ([D-Pro9[Spiro-gamma-Lactam]Leu10,Trp11]physalaemin (1-11)), markedly attenuated the response. Both prostaglandin F2alpha and the relatively selective FP receptor agonist, latanoprost acid, caused relaxation of the veins to about 50% of the precontracted state in the presence of GR 32191B ([1R-[1alpha(Z),2beta,3beta,5alpha]]-(+)-7-[5-([1,1'-b iphenyl]-4-ylmethoxy)-3-hydroxy-2-(1-piperidinyl)cyclopentyl]-4-he ptenoic acid), a thromboxane receptor antagonist (EC50: for prostaglandin F2alpha 7.9 x 10(-9) M, and for latanoprost acid 4.9 x 10(-9) M). L-NAME, as well as d...Continue Reading

References

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Citations

Mar 19, 2014·Phytochemistry·Maged E Mohamed, Colin M Lazarus
May 8, 1998·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·M Astin
Jul 30, 2004·Clinical & Experimental Ophthalmology·Cengiz AkarsuAhmet Ergin
Oct 28, 2005·Cardiovascular Drug Reviews·June ChenLarry A Wheeler
Jan 29, 2013·Prostaglandins & Other Lipid Mediators·Iwona DamsAndrzej Kutner
Mar 13, 2003·American Journal of Physiology. Renal Physiology·Osamu SaitoMatthew D Breyer
Oct 26, 2005·Biochemical and Biophysical Research Communications·Kae FukuyamaAkira Takeshita

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