PMID: 18418081Apr 18, 2008Paper

Mechanism of relapse in pediatric acute lymphoblastic leukemia

Cell Cycle
Michelle J HendersonMurray D Norris

Abstract

Relapse following initial chemotherapy remains a barrier to survival in approximately 20% of children suffering from acute lymphoblastic leukemia (ALL). Recently, to investigate the mechanism of relapse, we analysed clonal populations in 27 pairs of matched diagnosis and relapse ALL samples using PCR-based detection of multiple antigen receptor gene rearrangements. These clonal markers revealed the emergence of apparently new populations at relapse in 13 patients. In those cases where the new 'relapse clone' could be detected in the diagnosis population, there was a close correlation between length of first remission and quantity of the relapse clone in the diagnosis sample. A shorter length of time to first relapse correlated with a higher quantity of the relapsing clone at diagnosis. This observation, together with demonstrated differential chemosensitivity between sub-clones at diagnosis, indicates that relapse in ALL patients may commonly involve selection of a minor intrinsically resistant sub-clone that is undetectable by routine PCR-based methods. From a clinical perspective, relapse prediction may be improved with strategies to detect minor potentially resistant sub-clones early during treatment, hence allowing intensif...Continue Reading

Citations

Apr 21, 2011·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Fen ZhouRunming Jin
Mar 1, 2012·Leukemia·R ParameswaranN Heisterkamp
Apr 13, 2011·Blood·Frederik W van DelftMel Greaves
Dec 1, 2009·Cases Journal·Elisa Dorantes-AcostaAurora Medina-Sanson
Apr 7, 2009·British Journal of Haematology·Ulrike BacherTorsten Haferlach
Oct 28, 2011·Cell Cycle·Elena Campos-SanchezCésar Cobaleda
Mar 29, 2011·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Yong-Xian HuHe Huang
Aug 22, 2020·Curēus·Pham Nguyen TuongNguyen Thi Kim Hoa
Jun 16, 2021·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Nina RolfGregor S D Reid

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