PMID: 6958780Oct 1, 1982Paper

Mechanism of reperfusion arrhythmia prostaglandin as a washout metabolite

Journal of Electrocardiology
Y MiyazakiT Ozawa

Abstract

This study was designed to clarify the mechanism of reperfusion arrhythmia. In the mongrel dogs, the left anterior descending coronary artery was occluded for 15 min and then the ligation was released. The dogs were divided into two groups: one was the control group, and the other the indomethacin group in which indomethacin, an inhibitor of prostaglandin (PG) biosynthesis, was premedicated at 30 min before ligation. The ventricular multiple response threshold (VMRT), and plasma levels of K+, PG E and PG F2 alpha were measured in the great cardiac vein before and during occlusion, and after reperfusion. In the control group, during occlusion, VMRT decreased and did not return to normal soon after reperfusion. The levels of PG E and PG F2 alpha in the great cardiac vein did not change significantly during occlusion; however, PG E became significantly elevated after reperfusion. In the indomethacin group, the time course of VMRT was essentially similar to that of the control group during occlusion; however, lowering of VMRT after reperfusion was prevented significantly. The PG F2 alpha level in the great cardiac vein did not elevate after reperfusion or during occlusion. In both groups, the level of K+ in the great cardiac vein w...Continue Reading

References

Jun 1, 1978·Annals of Surgery·G M Lawrie, G C Morris
Nov 1, 1975·The American Journal of Cardiology·P J AxelrodB Lown
Apr 1, 1974·The American Journal of Cardiology·J T DawsonD A Cooley
Jun 1, 1966·American Heart Journal·A S Harris

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Citations

Feb 26, 1991·European Journal of Pharmacology·S TagliaviniC Bazzani
Feb 1, 1993·The International Journal of Biochemistry·T Siminiak, T Ozawa
Apr 1, 1986·Journal of Electrocardiology·M AjiokaT Ozawa
Sep 1, 1988·International Journal of Cardiology·M C SolimeneF Pileggi
Feb 1, 1986·International Journal of Cardiology·P M HoltP V Curry
Nov 1, 2001·The Cochrane Database of Systematic Reviews·M CheineK Wahlbeck

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