PMID: 2503924Jan 1, 1989Paper

Mechanism of replacement of non-parenchymal liver cells (NPLC) in murine radiation chimeras

Virchows Archiv. A, Pathological Anatomy and Histopathology
N FreudenbergM A Freudenberg

Abstract

The mechanism of cell replacement of non-parenchymal liver cells (NPLC) was investigated in an attempt to answer the question: to what extend are NPLC replaced by proliferation of local resident cells and to what extend by cells originating from the bone-marrow. The bone-marrow of mice was used, and H2k positive cells from F1 (B10.BR X B10.D2) hybrid mice were transplanted into irradiated H2k negative parent animals. Their NPLC were isolated and tested immunocytochemically with a monoclonal anti-H2k antibody for the presence of H2k positive cells. During the whole of the experiment (from the 5th to the 20th week following transplantation) H2k positive cells (macrophages and non-macrophages) were present, and made up an average of nearly one third of the NPLC. The H2k positive (immigrant) non-macrophages showed essentially more active DNA synthesis than these H2k negative cells. To increase cell turnover, we injected one group of animals with endotoxin. At the time of maximum replacement, more than 50% of the NPLC (macrophages and non-macrophages) were recruited from cells of bone-marrow origin. Note-worthy here was the proportionate level of the H2k positive macrophages (more than 70% of all liver macrophages). The DNA synthesi...Continue Reading

References

Jan 1, 1989·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·N FreudenbergM A Freudenberg
Jan 1, 1986·Virchows Archiv. A, Pathological Anatomy and Histopathology·N FreudenbergC Galanos
Mar 1, 1986·Cell and Tissue Kinetics·L BouwensE Wisse
Jun 1, 1969·European Journal of Biochemistry·C GalanosO Westphal

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Citations

Nov 1, 1995·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·H ImamuraP M Huet
Jan 1, 1992·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·N FreudenbergM A Freudenberg

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