Mechanism of resistance to benzalkonium chloride by Pseudomonas aeruginosa.

Applied and Environmental Microbiology
Y SakagamiT Tashima

Abstract

The mechanisms of resistance of Pseudomonas aeruginosa to benzalkonium chloride (BC) were studied. The effluence of cell components was observed in susceptible P. aeruginosa by electron microscopy, but resistant P. aeruginosa seemed to be undamaged. No marked changes in cell surface potential between Escherichia coli NIHJC-2 and a spheroplast strain were found. The contents of phospholipids (PL) and fatty and neutral lipids (FNL) in the cell walls of resistant P. aeruginosa were higher than those in the cell walls of susceptible P. aeruginosa. The amounts of BC adsorbed to PL and FNL of cell walls of BC-resistant P. aeruginosa were lower than those for BC-susceptible P. aeruginosa. Fifteen species of cellular fatty acids were identified by capillary gas chromatography and gas chromatography-mass spectrometry. The ability of BC to permeate the cell wall was reduced because of the increase in cellular fatty acids. These results suggested that the resistance of P. aeruginosa to BC is mainly a result of increased in the contents of PL and FNL. In resistant P. aeruginosa, the decrease in the amount of BC adsorbed is likely to be the result of increases in the contents of PL and FNL.

References

Nov 1, 1975·The Journal of Antibiotics·Y UmezawaH Umezawa
Jan 1, 1979·Advances in Microbial Physiology·H Nikaido, T Nakae
Mar 1, 1985·Microbiological Reviews·H Nikaido, M Vaara
Jan 1, 1968·The Journal of Antibiotics·S KondoH Umezawa
Feb 1, 1973·Antimicrobial Agents and Chemotherapy·M Brzezinska, J Davies
Aug 1, 1984·The Journal of Applied Bacteriology·P BroxtonP Gilbert
Feb 1, 1980·Journal of Pharmaceutical Sciences·G AndermannM Erhart
Nov 1, 1956·The Biochemical Journal·L H STICKLAND
Apr 1, 1952·Journal of Bacteriology·C E CHAPLIN
Jan 1, 1948·Advances in Protein Chemistry·F W PUTNAM
Jan 31, 1941·The Journal of Experimental Medicine·Z BakerB F Miller

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Citations

Jan 1, 1993·The Journal of Applied Bacteriology·V S Brözel, T E Cloete
Aug 28, 2014·Critical Reviews in Microbiology·Steven L PercivalBenjamin A Lipsky
Sep 13, 2003·Journal of Applied Microbiology·S LangsrudR Borgmann-Strahsen
Jun 1, 1994·The Journal of Applied Bacteriology·V S Brözel, T E Cloete
Aug 1, 2005·Journal of Food Protection·M MoormanJ Pestka
Apr 28, 2019·Applied and Environmental Microbiology·Beatriz Merchel Piovesan Pereira, Ilias Tagkopoulos
Mar 16, 2021·Frontiers in Microbiology·Beatriz Merchel Piovesan PereiraIlias Tagkopoulos
Jun 3, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Yinan WangYang Liu

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