Abstract
We previously reported that mesencephalic dopaminergic neurons are resistant to cytotoxicity induced by nitric oxide (NO). This study investigated the intracellular mechanism that protects dopaminergic neurons against NO toxicity in rat mesencephalic cultures. Peroxynitrite anion, an active metabolite of NO, caused significant cytotoxic effects against dopaminergic and nondopaminergic neurons, but NO caused cytotoxic effects restricted to nondopaminergic neurons. In addition, we studied the effects of ascorbate, an anti-oxidant, on NO-induced neurotoxicity against dopaminergic neurons and found that coadministration of ascorbate failed to affect resistance against NO-induced neurotoxicity. These findings suggest that the protecting mechanism from NO neurotoxicity in dopaminergic neurons is based on inhibition of conversion of NO to peroxynitrite anion, is independent of the NO redox state, and is possibly due to suppression of superoxide anion production. Furthermore, we investigated NO-induced neurotoxicity with or without pretreatment with sublethal doses of methylphenylpyridium ion (MPP+). Following pretreatment with 1 microM MPP+, which did not show significant cytotoxic effects against dopaminergic neurons, NO demonstrated...Continue Reading
References
Oct 2, 1992·Brain Research·Y TamuraH Shiomi
Jan 1, 1992·Neuron·D S Bredt, S H Snyder
Jun 1, 1992·Neuron·S Z LeiS A Lipton
Jan 1, 1992·Annals of Neurology·A H SchapiraC D Marsden
Jul 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·V L DawsonS H Snyder
Feb 1, 1991·Trends in Neurosciences·J Garthwaite
Apr 1, 1991·Trends in Pharmacological Sciences·S H Snyder, D S Bredt
Apr 1, 1991·Journal of Neurochemistry·R R RamsayT P Singer
Mar 1, 1990·Journal of Neurochemistry·A H SchapiraC D Marsden
Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J S BeckmanB A Freeman
Aug 16, 1990·Biochemical and Biophysical Research Communications·E HasegawaS Minakami
Dec 1, 1989·Annals of Neurology·W D ParkerJ K Parks
Jul 28, 1988·Nature·E HirschY A Agid
Mar 13, 1986·Biochemical and Biophysical Research Communications·B K SinhaG Krishna
Aug 1, 1988·Journal of the Neurological Sciences·Y MizunoT Saitoh
Aug 18, 1986·Life Sciences·R R RamsayT P Singer
Apr 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·J A JavitchS H Snyder
Aug 15, 1970·Nature·U K Laemmli
Jul 1, 1994·Neuroscience·I LaingH H Schmidt
Apr 28, 1995·European Journal of Pharmacology·Y KitamuraY Nomura
Jan 1, 1994·European Neurology·N Ogawa
Nov 17, 1994·Annals of the New York Academy of Sciences·S A LiptonJ S Stamler
Jan 1, 1994·Progress in Brain Research·A AkaikeN Nakata
Jun 22, 1993·The Journal of Comparative Neurology·M D Johnson, P M Ma
Nov 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·D A WinkJ B Mitchell
Jul 1, 1993·Neuroscience·P ZhangF Javoy-Agid
Aug 12, 1993·Nature·S A LiptonJ S Stamler
Feb 15, 1996·Journal of Neuroscience Research·H SawadaJ Kimura
Jan 1, 1996·Journal of Neuroscience Research·H SawadaJ Kimura
Citations
Dec 25, 2013·European Journal of Pharmacology·Sandra OsterGabriele Gille
Jul 26, 2003·Antioxidants & Redox Signaling·Manuchair Ebadi, Sushil K Sharma
Sep 29, 1999·Journal of Neurochemistry·M IbiA Akaike
Jun 2, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·H SawadaS Shimohama
Jan 4, 2001·Japanese Journal of Pharmacology·Y KitamuraT Taniguchi
Jun 7, 2005·Journal of Neurochemistry·Younghye MoonKyungjin Kim
Jul 12, 2001·The Journal of Biological Chemistry·K NakamuraU J Kang
Oct 14, 2006·Journal of Pharmacological Sciences·Takashi YanagidaHiroyoshi Ariga
Dec 10, 2003·Neuroreport·Noriko SakkaAkinori Akaike
May 22, 2009·Journal of Neurochemistry·Yasuhiko IzumiAkinori Akaike
Sep 8, 2017·Advanced Healthcare Materials·Tatsuya OsakiRoger D Kamm
Feb 28, 2002·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Akinori AkaikeToshiaki Kume
May 24, 2003·Brain Research·K ShimizuH Shiono
Dec 8, 1998·Journal of Neuroscience Research·H SawadaS Shimohama
Jul 29, 2000·European Journal of Pharmacology·D TerwelH W Steinbusch
Jul 2, 2003·Brain Research·Tomitsune KitagamiTatsurou Ohta
Aug 21, 2003·Trends in Molecular Medicine·Shun ShimohamaTakashi Taniguchi
Nov 18, 1998·Annals of Neurology·M UrushitaniJ Kimura