Mechanism of resveratrol in improving ovarian function in a rat model of premature ovarian insufficiency

The Journal of Obstetrics and Gynaecology Research
Ning Li, Lili Liu

Abstract

To investigate the mechanism of resveratrol treatment in chemically induced premature ovarian insufficiency (POI) in rats. Five-week-old specific pathogen-free healthy Sprague-Dawley female rats (n = 90) were randomly divided into five groups (n = 18): low-dose resveratrol (group A), moderate-dose resveratrol (group B), high-dose resveratrol (group C), model control group (group D) and blank control group (group E). POI was induced in rats from the resveratrol-treated groups and the model control group according to observed indexes using a previously established model (oral administration of tripterygium wilfordii polyglycoside tablet 50 mg/kg/day for 14 days). Western blot analysis was performed to compare levels of PI3K, p-PI3K, Akt, p-Akt, mTOR, p-mTOR, Bax, Bcl-2 and Caspase-3 in ovarian tissues of each group, and expression of p-Akt, p-mTOR, Bax, Bcl-2 and Caspase-3 was also evaluated by immunohistochemistry. Serum levels of malondialdehyde (MDA) and superoxide dismutase (SOD) were determined using enzyme-linked immunosorbent assay. Compared with controls, we found that serum MDA decreased and SOD increased in resveratrol-treated groups. In addition, we found increased expression of p-PI3K, p-Akt, p-mTOR and Bcl-2, and dec...Continue Reading

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Citations

Aug 3, 2020·Molecular Reproduction and Development·Dan LiuWei He
Jul 26, 2019·International Journal of Molecular Sciences·Yu JiangZezheng Pan
Sep 25, 2019·Clinical Medicine Insights. Reproductive Health·Zeev Blumenfeld
Apr 11, 2020·Reproductive Medicine and Biology·Asako Ochiai, Keiji Kuroda
Feb 12, 2021·Frontiers in Pharmacology·Liuqing YangQin Zhang
Dec 3, 2020·Antioxidants·Cristina Rodríguez-Varela, Elena Labarta
May 27, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Lingdi WangHongyan Yang
Jun 9, 2021·Phytotherapy Research : PTR·Alexander V Sirotkin
Jun 15, 2021·Journal of Cellular Physiology·Ling WangFenge Li
Jun 18, 2021·Mechanisms of Ageing and Development·Mónica B FrungieriMaría E Matzkin

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